CD24 (heat stable antigen, nectadrin), a novel keratinocyte differentiation marker, is preferentially expressed in areas of the hair follicle containing the colony-forming cells
Details
Serval ID
serval:BIB_F800FD5DFA6A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
CD24 (heat stable antigen, nectadrin), a novel keratinocyte differentiation marker, is preferentially expressed in areas of the hair follicle containing the colony-forming cells
Journal
Journal of Cell Science
ISSN
0021-9533 (Print)
Publication state
Published
Issued date
12/1996
Volume
109 ( Pt 13)
Pages
3035-45
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Research Support, Non-U.S. Gov't --- Old month value: Dec
Abstract
We have isolated, by subtractive and differential hybridization from a library constructed from keratinocyte colony-forming cells (K-CFCs), a cDNA coding for the rat CD24 (nectadrin, heat stable antigen). CD24, a glycoprotein thought to be involved in cell-cell adhesion and signalling, is highly expressed in keratinocytes located in the bulge area of the rat vibrissa which contains the most K-CFCs. CD24 is also expressed in the outer epithelial sheath of human hair follicles and in glabrous epidermis. However, its expression is not restricted to K-CFCs as demonstrated by cell sorting experiments, and it is thus not a specific marker of clonogenic keratinocytes. Rather, its preferential distribution in keratinocytes located in the most innervated area of the rat vibrissal follicle, i.e., the bulge, suggests that is function could be related to the tactile role of the hair follicle.
Keywords
3T3 Cells
Amino Acid Sequence
Animals
Antigens, CD/genetics/*immunology
Antigens, CD24
Base Sequence
Biological Markers
*Cell Differentiation
Cloning, Molecular
DNA, Complementary
Hair Follicle/cytology/*immunology
Humans
Keratinocytes/cytology/*immunology
*Membrane Glycoproteins
Mice
Molecular Sequence Data
RNA, Messenger
Rats
Rats, Inbred F344
Vibrissae/immunology
Pubmed
Web of science
Create date
28/01/2008 9:41
Last modification date
20/08/2019 17:24