Effect of indomethacin on the incidence of experimental Escherichia coli pyelonephritis

Details

Serval ID
serval:BIB_F788D0CA216A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Effect of indomethacin on the incidence of experimental Escherichia coli pyelonephritis
Journal
Infection and Immunity
Author(s)
Glauser  M. P., Francioli  P. B., Bille  J., Bonard  M., Meylan  P.
ISSN
0019-9567 (Print)
Publication state
Published
Issued date
05/1983
Volume
40
Number
2
Pages
529-33
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Abstract
In the presence of temporary obstruction (20 h), ascending Escherichia coli urinary infection leads to irreversible acute exudative pyelonephritis (AEP) in rats. The purpose of the present study was to investigate the early inflammatory events which take place in response to the presence of bacteria in the kidney parenchyma and lead to the development of AEP. Rats were given indomethacin before and during the obstructive phase of kidney infection and were sacrificed at different times thereafter. Although renal infection (as defined by bacterial counts) was equally frequent (76%) and severe in indomethacin-treated and control rats sacrificed at the end of the obstructive period, it was found that the incidence of AEP (as defined by the inflammatory response of the kidney elicited by bacteria) 2 days after removal of the obstruction was significantly reduced from 74% in controls given water to 48% in indomethacin-treated animals (P = 0.02). Rat kidneys without AEP had bacterial counts of 10(2)/g. Since indomethacin apparently had no direct antibacterial activity against E. coli and no effect on urine osmolalities, it is likely that the reduction in the incidence of AEP and the concomitant eradication of bacteria after removal of the obstruction was due to an effect of indomethacin that is related to the renal response to infection. This was possibly due to decreased inflammation, as indicated by the fact that when pyelonephritis developed in indomethacin-treated rats it was less severe than in controls. These results suggest that if inflammation can be mitigated when bacteria are present in the kidney during obstruction, the bacteria may be cleared spontaneously once the normal urinary flow is restored.
Keywords
Animals Escherichia coli Infections/prevention & control Indomethacin/*pharmacology Male Pyelonephritis/*prevention & control Rats Ureteral Obstruction/*drug therapy
Pubmed
Web of science
Create date
25/01/2008 18:07
Last modification date
03/03/2018 22:50
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