Transmission of MRSA and MSSA between humans and farm animals

Details

Serval ID
serval:BIB_F6B278EFF3DF
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Title
Transmission of MRSA and MSSA between humans and farm animals
Title of the conference
Microbes rule the world : 68th Annual Assembly of the SSM, Amphipôle, University of Lausanne, 4-5 June, 2009
Author(s)
Sakwinska Olga, Oppliger Anne, Giddey Marlyse, Moreillon Martine, Waldvogel Andreas, Moreillon Philippe
Publisher
Swiss Society for Microbiology
Publication state
Published
Issued date
2009
Pages
P050, 110
Language
english
Notes
SAPHIRID:79436
Abstract
Human nares are the main niche of Staphylococcus aureus, but farm animals can be also infected (cows) or colonized (pigs) constituting significant reservoir of this pathogen. Previous studies indicated that human and animal strains are quite distinct but the extent of cross-species specialization and transmission remains largely unknown. However, recent reports from several European countries as well as USA and Canada have indicated that employment in farming is an emerging risk factor for MRSA carriage. Pigs were found to be frequently colonized with MRSA, usually with a strain belonging to CC398. It is not known whether animal-human transmission was specific to this particular MRSA strain. S. aureus isolates from cow mastitis and pig colonization isolates were collected in parallel to nasal swab isolates from the animals' caretakers. The isolates were genotyped by AFLP, spatyping, and when appropriate by MLST. The isolates from cow mastitis were genetically uniform in comparison with human isolates. They were quite distinct from farmers\' carriage isolates, indicating pronounced hostspecialization. However, several cases where an infected cow and a colonized farmer had the same strain were detected, including one farm where two farmers were colonized and two cows were infected with MRSA belonging to CC398. Pig isolates were genetically more diverse than cow isolates. They were different from both human and cow isolates with one notable exception. Large fraction of pigs (20%) and pig caretakers (50%) were colonized with isolates belonging to CC398, majority of which were MSSA (2 cases of MRSA). These results indicate that host specialization in S. aureus is quite pronounced. Transmission between humans and farm animals was consequently quite rare. Both MSSA and MRSA strains belonging to otherwise pig-specific CC398 had increased capacity to colonize humans. Study of the genetic factors responsible for host specialization is underway.
Keywords
Methicillin-Resistant Staphylococcus aureus , Staphylococcal Infections , Staphylococcus aureus , Guinea Pigs , Humans , Animals
Create date
27/01/2010 13:20
Last modification date
20/08/2019 17:23
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