Tuberculosis diagnostics and biomarkers: needs, challenges, recent advances, and opportunities.

Details

Ressource 1Download: serval:BIB_F65424B09DBF.P001 (425.90 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_F65424B09DBF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Tuberculosis diagnostics and biomarkers: needs, challenges, recent advances, and opportunities.
Journal
Journal of Infectious Diseases
Author(s)
McNerney R., Maeurer M., Abubakar I., Marais B., McHugh T.D., Ford N., Weyer K., Lawn S., Grobusch M.P., Memish Z., Squire S.B., Pantaleo G., Chakaya J., Casenghi M., Migliori G.B., Mwaba P., Zijenah L., Hoelscher M., Cox H., Swaminathan S., Kim P.S., Schito M., Harari A., Bates M., Schwank S., O'Grady J., Pletschette M., Ditui L., Atun R., Zumla A.
ISSN
1537-6613 (Electronic)
ISSN-L
0022-1899
Publication state
Published
Issued date
2012
Volume
205
Number
Suppl. 2
Pages
S147-S158
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Tuberculosis is unique among the major infectious diseases in that it lacks accurate rapid point-of-care diagnostic tests. Failure to control the spread of tuberculosis is largely due to our inability to detect and treat all infectious cases of pulmonary tuberculosis in a timely fashion, allowing continued Mycobacterium tuberculosis transmission within communities. Currently recommended gold-standard diagnostic tests for tuberculosis are laboratory based, and multiple investigations may be necessary over a period of weeks or months before a diagnosis is made. Several new diagnostic tests have recently become available for detecting active tuberculosis disease, screening for latent M. tuberculosis infection, and identifying drug-resistant strains of M. tuberculosis. However, progress toward a robust point-of-care test has been limited, and novel biomarker discovery remains challenging. In the absence of effective prevention strategies, high rates of early case detection and subsequent cure are required for global tuberculosis control. Early case detection is dependent on test accuracy, accessibility, cost, and complexity, but also depends on the political will and funder investment to deliver optimal, sustainable care to those worst affected by the tuberculosis and human immunodeficiency virus epidemics. This review highlights unanswered questions, challenges, recent advances, unresolved operational and technical issues, needs, and opportunities related to tuberculosis diagnostics.
Pubmed
Web of science
Open Access
Yes
Create date
19/05/2012 19:37
Last modification date
25/09/2019 7:11
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