Screening for infectious diseases

Details

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Serval ID
serval:BIB_F6491EC18084
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Screening for infectious diseases
Journal
Child's Nervous System
Author(s)
Gerber  S., Hohlfeld  P.
ISSN
0256-7040 (Print)
Publication state
Published
Issued date
08/2003
Volume
19
Number
7-8
Pages
429-32
Notes
Comparative Study
Journal Article --- Old month value: Aug
Abstract
INTRODUCTION: Fetal brain injury is an essential cause of lifelong morbidity. Infection appears as a cause of brain damage. Apart from chorioamnionitis, screening for infectious diseases must be considered in pregnancies with a risk of congenital infection or cases with abnormal cerebral ultrasound findings. DISCUSSION: Congenital infections include most of the major components of the TORCH complex: toxoplasmosis, rubella, cytomegalovirus, herpes, and varicella. Seronegative mothers can develop primary infection, which carries a risk of vertical transmission. The timing of the infection is a critical point, because fetal damage often depends on the gestational age at which acute maternal infection took place and occurs more likely in the first half of pregnancy. Antenatal ultrasound can detect brain abnormalities, like hydrocephalus, periventricular leukomalacia, calcifications or hemorrhage. Maternal serologic tests must be performed to look for an infectious etiology; the most frequent agents are the components of the TORCH complex. But additional serology must include parvovirus B19, HIV, and coxsackieviruses.
Keywords
Brain Injuries/*diagnosis/virology Chickenpox/diagnosis Cytomegalovirus/pathogenicity Female Fetal Diseases/*diagnosis/microbiology Herpesvirus 1, Cercopithecine/pathogenicity Humans *Mass Screening Pregnancy Pregnancy Complications, Infectious/*diagnosis/virology Rubella/diagnosis/virology Time Factors Toxoplasmosis, Congenital/diagnosis/virology Ultrasonography, Prenatal/methods
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 12:12
Last modification date
01/10/2019 7:20
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