Developmental Constraints on Genome Evolution in Four Bilaterian Model Species.

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Version: Final published version
Serval ID
serval:BIB_F61F6F919170
Type
Article: article from journal or magazin.
Collection
Publications
Title
Developmental Constraints on Genome Evolution in Four Bilaterian Model Species.
Journal
Genome biology and evolution
Author(s)
Liu J., Robinson-Rechavi M.
ISSN
1759-6653 (Electronic)
ISSN-L
1759-6653
Publication state
Published
Issued date
01/09/2018
Peer-reviewed
Oui
Volume
10
Number
9
Pages
2266-2277
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Developmental constraints on genome evolution have been suggested to follow either an early conservation model or an "hourglass" model. Both models agree that late development strongly diverges between species, but debate on which developmental period is the most conserved. Here, based on a modified "Transcriptome Age Index" approach, that is, weighting trait measures by expression level, we analyzed the constraints acting on three evolutionary traits of protein coding genes (strength of purifying selection on protein sequences, phyletic age, and duplicability) in four species: Nematode worm Caenorhabditis elegans, fly Drosophila melanogaster, zebrafish Danio rerio, and mouse Mus musculus. In general, we found that both models can be supported by different genomic properties. Sequence evolution follows an hourglass model, but the evolution of phyletic age and of duplicability follow an early conservation model. Further analyses indicate that stronger purifying selection on sequences in the middle development are driven by temporal pleiotropy of these genes. In addition, we report evidence that expression in late development is enriched with retrogenes, which usually lack efficient regulatory elements. This implies that expression in late development could facilitate transcription of new genes, and provide opportunities for acquisition of function. Finally, in C. elegans, we suggest that dosage imbalance could be one of the main factors that cause depleted expression of high duplicability genes in early development.
Keywords
Animals, Caenorhabditis elegans/genetics, Drosophila melanogaster/genetics, Evolution, Molecular, Gene Duplication, Gene Expression Regulation, Developmental, Genome, Mice/genetics, Phylogeny, Transcriptome, Zebrafish/genetics
Pubmed
Web of science
Open Access
Yes
Create date
13/08/2018 14:25
Last modification date
20/08/2019 16:22
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