Feeling Exhausted? Tuning Irf4 Energizes Dysfunctional T Cells.
Details
State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_F6047C7A6B9F
Type
Article: article from journal or magazin.
Publication sub-type
Editorial
Collection
Publications
Institution
Title
Feeling Exhausted? Tuning Irf4 Energizes Dysfunctional T Cells.
Journal
Immunity
ISSN
1097-4180 (Electronic)
ISSN-L
1074-7613
Publication state
Published
Issued date
19/12/2017
Peer-reviewed
Oui
Volume
47
Number
6
Pages
1009-1011
Language
english
Notes
Publication types: Journal Article ; Comment
Publication Status: ppublish
Publication Status: ppublish
Abstract
The regulatory mechanisms governing T cell exhaustion remain incompletely understood. Man et al. (2017) and Wu et al. (2017) report that the T cell receptor responsive transcription factor Irf4 promotes T cell exhaustion in chronic viral infection but dampens exhaustion in response to tissue allografts.
Keywords
CD8-Positive T-Lymphocytes, Gene Expression Regulation, Humans, Male, Receptors, Antigen, T-Cell
Pubmed
Web of science
Create date
10/01/2018 8:14
Last modification date
18/07/2020 6:10
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