Codeine accumulation and elimination in larvae, pupae, and imago of the blowfly Lucilia sericata and effects on its development.

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Serval ID
serval:BIB_F5F4C1714BC4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Codeine accumulation and elimination in larvae, pupae, and imago of the blowfly Lucilia sericata and effects on its development.
Journal
International Journal of Legal Medicine
Author(s)
Kharbouche H., Augsburger M., Cherix D., Sporkert F., Giroud C., Wyss C., Champod C., Mangin P.
ISSN
0937-9827[print], 0937-9827[linking]
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
122
Number
3
Pages
205-211
Language
english
Abstract
The aim of this study was to evaluate the reliability of insect larvae as samples for toxicological investigations. For this purpose, larvae of Lucilia sericata were reared on samples of minced pig liver treated with different concentrations of codeine: therapeutic, toxic, and potentially lethal doses. Codeine was detected in all tested larvae, confirming the reliability of these specimens for qualitative toxicology analysis. Furthermore, concentrations measured in larvae were correlated with levels in liver tissue. These observations bring new elements regarding the potential use of opiates concentrations in larvae for estimation of drug levels in human tissues. Morphine and norcodeine, two codeine metabolites, have been also detected at different concentrations depending on the concentration of codeine in pig liver and depending on the substance itself. The effects of codeine on the development of L. sericata were also investigated. Results showed that a 29-h interval bias on the evaluation of the larval stage duration calculated from the larvae weight has to be considered if codeine was present in the larvae substrate. Similarly, a 21-h interval bias on the total duration of development, from egg to imago, has to be considered if codeine was present in the larvae substrate.
Keywords
Animals, Codeine/analogs & derivatives, Codeine/analysis, Diptera/chemistry, Forensic Toxicology, Gas Chromatography-Mass Spectrometry, Larva/chemistry, Liver/chemistry, Morphine/analysis, Narcotics/analysis, Narcotics/toxicity, Pupa/chemistry, Swine
Pubmed
Web of science
Open Access
Yes
Create date
25/06/2008 14:49
Last modification date
01/10/2019 7:20
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