Activation and manipulation of inflammasomes and pyroptosis during bacterial infections.

Details

Serval ID
serval:BIB_F5EFACC64C78
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Activation and manipulation of inflammasomes and pyroptosis during bacterial infections.
Journal
The Biochemical journal
Author(s)
Bernard E.M., Broz P.
ISSN
1470-8728 (Electronic)
ISSN-L
0264-6021
Publication state
Published
Issued date
14/04/2022
Peer-reviewed
Oui
Volume
479
Number
7
Pages
867-882
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Following detection of pathogen infection and disrupted cellular homeostasis, cells can activate a range of cell death pathways, such as apoptosis, necroptosis and pyroptosis, as part of their defence strategy. The initiation of pro-inflammatory, lytic pyroptosis is controlled by inflammasomes, which respond to a range of cellular perturbations. As is true for many host defence pathways, pathogens have evolved multiple mechanisms to subvert this pathway, many of which have only recently been described. Herein, we will discuss the mechanisms by which inflammasomes sense pathogen invasion and initiate pyroptosis and the effector mechanisms used by pathogens to suppress this pathway and preserve their niche.
Keywords
Apoptosis, Bacterial Infections, Cell Death, Humans, Inflammasomes/metabolism, Pyroptosis, bacterial infections, inflammasomes, pyroptosis
Pubmed
Web of science
Create date
25/04/2022 11:14
Last modification date
21/05/2022 6:34
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