A functional microsatellite of the macrophage migration inhibitory factor gene associated with meningococcal disease.

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State: Public
Version: author
Serval ID
serval:BIB_F5DFBCC583E6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A functional microsatellite of the macrophage migration inhibitory factor gene associated with meningococcal disease.
Journal
Faseb Journal
Author(s)
Renner Pascal, Roger Thierry, Bochud Pierre-Yves, Sprong Tom, Sweep Fred C.G.J., Bochud Murielle, Faust Saul N., Haralambous Elene, Betts Helen, Chanson Anne-Laure, Knaup Reymond Marlies, Mermel Elliott, Erard Veronique, van Deuren Marcel, Read Robert C., Levin Michael, Calandra Thierry
ISSN
1530-6860 (Electronic)
ISSN-L
0892-6638
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
26
Number
2
Pages
907-916
Language
english
Abstract
Macrophage migration inhibitory factor (MIF) is an abundantly expressed proinflammatory cytokine playing a critical role in innate immunity and sepsis and other inflammatory diseases. We examined whether functional MIF gene polymorphisms (-794 CATT(5-8) microsatellite and -173 G/C SNP) were associated with the occurrence and outcome of meningococcal disease in children. The CATT(5) allele was associated with the probability of death predicted by the Pediatric Index of Mortality 2 (P=0.001), which increased in correlation with the CATT(5) copy number (P=0.04). The CATT(5) allele, but not the -173 G/C alleles, was also associated with the actual mortality from meningoccal sepsis [OR 2.72 (1.2-6.4), P=0.02]. A family-based association test (i.e., transmission disequilibrium test) performed in 240 trios with 1 afflicted offspring indicated that CATT(5) was a protective allele (P=0.02) for the occurrence of meningococcal disease. At baseline and after stimulation with Neisseria meningitidis in THP-1 monocytic cells or in a whole-blood assay, CATT(5) was found to be a low-expression MIF allele (P=0.005 and P=0.04 for transcriptional activity; P=0.09 and P=0.09 for MIF production). Taken together, these data suggest that polymorphisms of the MIF gene affecting MIF expression are associated with the occurrence, severity, and outcome of meningococcal disease in children.
Pubmed
Web of science
Create date
25/10/2011 16:36
Last modification date
20/08/2019 17:22
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