Acid inhibition on the first day of dosing: comparison of four proton pump inhibitors

Details

Serval ID
serval:BIB_F5DF6B6D9675
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Acid inhibition on the first day of dosing: comparison of four proton pump inhibitors
Journal
Alimentary Pharmacology and Therapeutics
Author(s)
Pantoflickova  D., Dorta  G., Ravic  M., Jornod  P., Blum  A. L.
ISSN
0269-2813 (Print)
Publication state
Published
Issued date
06/2003
Volume
17
Number
12
Pages
1507-14
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial --- Old month value: Jun 15
Abstract
BACKGROUND: Rapid and consistent acid suppression on the first day of dosing may be important in treating acid-related disorders. AIM: To compare the antisecretory activity and onset of action of single doses of rabeprazole, lansoprazole, pantoprazole, omeprazole capsule, omeprazole multiple unit pellet system (MUPS) tablet and placebo in healthy Helicobacter pylori-negative subjects. METHODS: This cross-over, double-blind, randomized study was performed in 18 H. pylori-negative subjects. Twenty-four-hour intragastric pH monitoring was performed on the day of treatment (once-daily dose of rabeprazole 20 mg, lansoprazole 30 mg, pantoprazole 40 mg, omeprazole capsule 20 mg, omeprazole MUPS tablet 20 mg or placebo). RESULTS: The intragastric pH (3.4) and time at pH > 4 during the 24 h post-dose (8.0 h) were significantly greater with rabeprazole than with lansoprazole, pantoprazole, omeprazole capsule, omeprazole MUPS tablet or placebo (P <or= 0.04 for rabeprazole vs. the others). Daytime and night-time pH values were higher with rabeprazole and lansoprazole than with pantoprazole, omeprazole capsule and omeprazole MUPS tablet (P </= 0.04). CONCLUSION: Rabeprazole was the most potent acid inhibitor of all the proton pump inhibitors tested during the first day of dosing.
Keywords
2-Pyridinylmethylsulfinylbenzimidazoles Adolescent Adult Antacids/*administration & dosage Benzimidazoles/administration & dosage Cross-Over Studies Double-Blind Method Female Gastric Acid/*secretion Humans Hydrogen-Ion Concentration Male Middle Aged Omeprazole/administration & dosage/analogs & derivatives Proton Pumps/*antagonists & inhibitors Sulfoxides/administration & dosage Time Factors
Pubmed
Web of science
Create date
25/01/2008 16:48
Last modification date
20/08/2019 17:22
Usage data