Connexins and pannexins: from biology towards clinical targets.

Details

Ressource 1Download: smw.2016.14365.pdf (1228.60 [Ko])
State: Public
Version: author
Serval ID
serval:BIB_F5B2F12EA9B6
Type
Article: article from journal or magazin.
Collection
Publications
Title
Connexins and pannexins: from biology towards clinical targets.
Journal
Swiss medical weekly
Author(s)
Meda P., Haefliger J.A.
ISSN
1424-3997 (Electronic)
ISSN-L
0036-7672
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
146
Pages
w14365
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Efficient cell communication is a prerequisite for the coordinated function of tissues and organs. In vertebrates, this communication is mediated by a variety of mechanisms, including the exchange of molecules between cells, and between cells and the extracellular medium, via membrane channels made of connexin and pannexin proteins. These channels are a necessary component of all human tissues. Here, we review the biological essentials of the connexin and pannexin families, and the roles of these proteins in the function of cells which are central to major human diseases. We then discuss how connexins and pannexins participate in human pathology, and the clinical perspectives that this knowledge opens.

Keywords
Biological Transport/physiology, Cell Communication, Connexins/genetics, Connexins/metabolism, Endothelial Cells/metabolism, Gap Junctions/metabolism, Humans, Insulin-Secreting Cells/metabolism, Ion Channels/metabolism, Neoplasms/physiopathology, Neovascularization, Pathologic/metabolism, Renin/biosynthesis
Pubmed
Web of science
Open Access
Yes
Create date
25/04/2017 17:17
Last modification date
20/08/2019 17:22
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