The number of patients whose immune responses are impaired is increasing over the years due to larger use of immunosuppressive therapies aiming at treating malignant, autoimmune or inflammatory diseases. These patients are at high risk of infections, many of which are preventable by vaccination. However, this population is often under-vaccinated because of negligence but also of concerns regarding the safety of these vaccines, the potential risk of exacerbation of underlying disease or vaccine efficacy. In this article, we are trying to stratify different patient groups based on different immunosuppressive treatments and to present adequate vaccination schemes according to the recommendations found in medical literature.