Plasma triacylglycerols are biomarkers of β-cell function in mice and humans.

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State: Public
Version: author
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_F588B3D1D116
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Plasma triacylglycerols are biomarkers of β-cell function in mice and humans.
Journal
Molecular metabolism
Author(s)
Sánchez-Archidona A.R., Cruciani-Guglielmacci C., Roujeau C., Wigger L., Lallement J., Denom J., Barovic M., Kassis N., Mehl F., Weitz J., Distler M., Klose C., Simons K., Ibberson M., Solimena M., Magnan C., Thorens B.
ISSN
2212-8778 (Electronic)
ISSN-L
2212-8778
Publication state
Published
Issued date
09/10/2021
Peer-reviewed
Oui
Volume
54
Pages
101355
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
To find plasma biomarkers prognostic of type 2 diabetes, which could also inform on pancreatic β-cell deregulations or defects in the function of insulin target tissues.
We conducted a systems biology approach to characterize the plasma lipidomes of C57Bl/6J, DBA/2J, and BALB/cJ mice under different nutritional conditions, as well as their pancreatic islet and liver transcriptomes. We searched for correlations between plasma lipids and tissue gene expression modules.
We identified strong correlation between plasma triacylglycerols (TAGs) and islet gene modules that comprise key regulators of glucose- and lipid-regulated insulin secretion and of the insulin signaling pathway, the two top hits were Gck and Abhd6 for negative and positive correlations, respectively. Correlations were also found between sphingomyelins and islet gene modules that overlapped in part with the gene modules correlated with TAGs. In the liver, the gene module most strongly correlated with plasma TAGs was enriched in mRNAs encoding fatty acid and carnitine transporters as well as multiple enzymes of the β-oxidation pathway. In humans, plasma TAGs also correlated with the expression of several of the same key regulators of insulin secretion and the insulin signaling pathway identified in mice. This cross-species comparative analysis further led to the identification of PITPNC1 as a candidate regulator of glucose-stimulated insulin secretion.
TAGs emerge as biomarkers of a liver-to-β-cell axis that links hepatic β-oxidation to β-cell functional mass and insulin secretion.
Keywords
PITPNC1, Triacylglycerols, plasma biomarkers, systems biology, type 2 diabetes, ß-cell function, Biomarkers, Systems biology, Type 2 diabetes, β-cell function
Pubmed
Web of science
Open Access
Yes
Create date
19/10/2021 12:28
Last modification date
25/02/2022 7:37
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