The Keap1/Nrf2 Signaling Pathway in the Thyroid-2020 Update.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_F5831CDC48DF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The Keap1/Nrf2 Signaling Pathway in the Thyroid-2020 Update.
Journal
Antioxidants
Author(s)
Thanas C., Ziros P.G., Chartoumpekis D.V., Renaud C.O., Sykiotis G.P.
ISSN
2076-3921 (Print)
ISSN-L
2076-3921
Publication state
Published
Issued date
04/11/2020
Peer-reviewed
Oui
Volume
9
Number
11
Pages
E1082
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
The thyroid gland has a special relationship with oxidative stress. On the one hand, like all other tissues, it must defend itself against reactive oxygen species (ROS). On the other hand, unlike most other tissues, it must also produce reactive oxygen species in order to synthesize its hormones that contribute to the homeostasis of other tissues. The thyroid must therefore also rely on antioxidant defense systems to maintain its own homeostasis in the face of continuous self-exposure to ROS. One of the main endogenous antioxidant systems is the pathway centered on the transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) and its cytoplasmic inhibitor Kelch-like ECH-associated protein 1 (Keap1). Over the last few years, multiple links have emerged between the Keap1/Nrf2 pathway and thyroid physiology, as well as various thyroid pathologies, including autoimmunity, goiter, hypothyroidism, hyperthyroidism, and cancer. In the present mini-review, we summarize recent studies shedding new light into the roles of Keap1/Nrf2 signaling in the thyroid.
Keywords
Keap1 (Kelch-like ECH-associated protein 1), Nrf2 (nuclear factor erythroid 2-related factor 2), antioxidant, goiter, oxidative stress, thyroglobulin, thyroid
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Projects / 31003A_153062
Swiss National Science Foundation / Projects / 31003A_182105
Swiss National Science Foundation / Projects / IZSEZ0_193623
Swiss National Science Foundation / Projects / IZCOZ0_177070
Fondation Leenaards / Fellowship for Academic Promotion in Clinical Medicine
Other / European Cooperation in Science and Technology (COST) Action CA16112 (NutRedOx)
Other / Exchange in Endocrinology Expertise (3E) Fellowship
Create date
22/11/2020 12:33
Last modification date
16/12/2020 7:24
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