Bacillus cereus bacteremia with central nervous system involvement: A neuropathological study.

Details

Ressource 1Download: pmid29035192.pdf (2476.47 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_F5647B145155
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Bacillus cereus bacteremia with central nervous system involvement: A neuropathological study.
Journal
Clinical neuropathology
Author(s)
Brouland J.P., Sala N., Tusgul S., Rebecchini C., Kovari E.
ISSN
0722-5091 (Print)
ISSN-L
0722-5091
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
37
Number
1
Pages
22-27
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Abstract
<i>Bacillus cereus</i> is a widely-distributed, gram-positive or variable, rod-shaped bacterium frequently considered a contaminant in clinical specimens. It is recognized as a potential pathogen inducing self-limiting emetic or diarrheal food poisoning or localized infection in immunocompetent patients. True <italic>B. cereus</italic> bacteremia is uncommon and mainly observed in fragile patients, notably in immunocompromised individuals. We report clinical, radiological, and pathological findings of a 64-year-old patient with a history of acute myeloid leukemia who initially presented a fever while neutropenic after the induction of a second cycle of chemotherapy. He developed <italic>B. cereus</italic> bacteremia with invasive infection and a fatal outcome. The clinical and radiological data of this case are compared to a previously-published series of 21 patients from our institution with <italic>B. cereus</italic> bacteremia. This study highlights the clinical challenge to diagnose <italic>B. cereus</italic> and the importance of the delay between the detection of <italic>B. cereus</italic> and the initiation of an effective targeted antibiotic therapy. This case presented an aggressive evolution with multiple necrotic and hemorrhagic foci in the brain. Upon histological examination, <italic>B. cereus</italic> virulence was notably reflected by the dissection of blood vessel walls by the bacilli and luminal occlusion, a pattern that has not been yet reported.
.
Keywords
Bacillus cereus/cytology, Bacteremia/diagnosis, Bacteremia/pathology, Brain/pathology, Humans, Immunocompromised Host/physiology, Male, Middle Aged, Nervous System Diseases/diagnosis, Nervous System Diseases/pathology, Neuropathology/methods
Pubmed
Web of science
Open Access
Yes
Create date
26/01/2018 14:55
Last modification date
20/08/2019 17:22
Usage data