Lymphotoxin-Dependent B Cell-FRC Crosstalk Promotes De Novo Follicle Formation and Antibody Production following Intestinal Helminth Infection.

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Version: Final published version
Serval ID
serval:BIB_F542588AD672
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lymphotoxin-Dependent B Cell-FRC Crosstalk Promotes De Novo Follicle Formation and Antibody Production following Intestinal Helminth Infection.
Journal
Cell Reports
Author(s)
Dubey L.K., Lebon L., Mosconi I., Yang C.Y., Scandella E., Ludewig B., Luther S.A., Harris N.L.
ISSN
2211-1247 (Electronic)
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
15
Number
7
Pages
1527-1541
Language
english
Abstract
Secondary lymphoid tissues provide specialized niches for the initiation of adaptive immune responses and undergo a remarkable expansion in response to inflammatory stimuli. Although the formation of B cell follicles was previously thought to be restricted to the postnatal period, we observed that the draining mesenteric lymph nodes (mLN) of helminth-infected mice form an extensive number of new, centrally located, B cell follicles in response to IL-4Rα-dependent inflammation. IL-4Rα signaling promoted LTα1β2 (lymphotoxin) expression by B cells, which then interacted with CCL19 positive stromal cells to promote lymphoid enlargement and the formation of germinal center containing B cell follicles. Importantly, de novo follicle formation functioned to promote both total and parasite-specific antibody production. These data reveal a role for type 2 inflammation in promoting stromal cell remodeling and de novo follicle formation by promoting B cell-stromal cell crosstalk.
Pubmed
Web of science
Open Access
Yes
Create date
29/05/2016 15:14
Last modification date
20/08/2019 17:22
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