Regulation of chromosomal replication in Caulobacter crescentus.

Details

Serval ID
serval:BIB_F502766183C8
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Regulation of chromosomal replication in Caulobacter crescentus.
Journal
Plasmid
Author(s)
Collier J.
ISSN
1095-9890 (Electronic)
ISSN-L
0147-619X
Publication state
Published
Issued date
2012
Volume
67
Number
2
Pages
76-87
Language
english
Abstract
The alpha-proteobacterium Caulobacter crescentus is characterized by its asymmetric cell division, which gives rise to a replicating stalked cell and a non-replicating swarmer cell. Thus, the initiation of chromosomal replication is tightly regulated, temporally and spatially, to ensure that it is coordinated with cell differentiation and cell cycle progression. Waves of DnaA and CtrA activities control when and where the initiation of DNA replication will take place in C. crescentus cells. The conserved DnaA protein initiates chromosomal replication by directly binding to sites within the chromosomal origin (Cori), ensuring that DNA replication starts once and only once per cell cycle. The CtrA response regulator represses the initiation of DNA replication in swarmer cells and in the swarmer compartment of pre-divisional cells, probably by competing with DnaA for binding to Cori. CtrA and DnaA are controlled by multiple redundant regulatory pathways that include DNA methylation-dependent transcriptional regulation, temporally regulated proteolysis and the targeting of regulators to specific locations within the cell. Besides being critical regulators of chromosomal replication, CtrA and DnaA are also master transcriptional regulators that control the expression of many genes, thus connecting DNA replication with other events of the C. crescentus cell cycle.
Keywords
Caulobacter crescentus, DNA replication, DnaA, CtrA, Proteolysis, Response regulator
Pubmed
Web of science
Create date
03/04/2012 15:08
Last modification date
20/08/2019 17:21
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