Relationship between prostate-specific antigen kinetics and detection rate of radiolabelled choline PET/CT in restaging prostate cancer patients: a meta-analysis.

Details

Serval ID
serval:BIB_F4CF391431EC
Type
Article: article from journal or magazin.
Collection
Publications
Title
Relationship between prostate-specific antigen kinetics and detection rate of radiolabelled choline PET/CT in restaging prostate cancer patients: a meta-analysis.
Journal
Clinical chemistry and laboratory medicine
Author(s)
Treglia G., Ceriani L., Sadeghi R., Giovacchini G., Giovanella L.
ISSN
1437-4331 (Electronic)
ISSN-L
1434-6621
Publication state
Published
Issued date
05/2014
Peer-reviewed
Oui
Volume
52
Number
5
Pages
725-733
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis
Publication Status: ppublish
Abstract
The aim of the article was to systematically review published data about the relationship between prostate-specific antigen (PSA) kinetics, including PSA doubling time (PSAdt) and PSA velocity (PSAvel), and detection rate (DR) of positron emission tomography/computed tomography (PET/CT) using radiolabelled choline in restaging prostate cancer (PCa).
A comprehensive literature search of studies published through July 2013 regarding the relationship between PSA kinetics and DR of radiolabelled choline PET/CT was carried out. Furthermore, a meta-analysis was performed in order to establish the DR of radiolabelled choline PET/CT using different cut-off values of PSAdt (≤ or >6 months) and PSAvel [>1 or ≤1 ng/(mL year) and >2 or ≤2 ng/(mL year)]. Moreover, a pooled analysis to establish whether PSAdt and PSAvel (using the abovementioned cut-off values) may predict positive PET/CT results was carried out.
Fourteen articles were selected. The pooled DR of radiolabelled choline PET/CT in restaging PCa was 58% [95% confidence interval (CI) 55-60]. Most articles reported a relationship between PSA kinetics and DR of PET/CT. Pooled DR of radiolabelled choline PET/CT increased to 65% (95% CI 58-71) when PSAdt was ≤6 months and to 71% (95% CI 66-76) and 77% (95% CI 71-82) when PSAvel was >1 or >2 ng/(mL year), respectively. PSAdt ≤6 months and PSAvel >1 or >2 ng/(mL year) proved to be relevant factors in predicting the positive result of radiolabelled choline PET/CT.
Due to the strong relationship between PSA kinetics and DR of radiolabelled choline PET/CT, beyond PSA values, PSAdt and PSAvel should be taken into account in the selection of PCa patients who should undergo radiolabelled choline PET/CT for restaging.

Keywords
Carbon Radioisotopes/chemistry, Choline/chemistry, Databases, Factual, Fluorine Radioisotopes/chemistry, Humans, Kinetics, Male, Positron-Emission Tomography, Prostate-Specific Antigen/blood, Prostate-Specific Antigen/metabolism, Prostatic Neoplasms/diagnosis, Prostatic Neoplasms/diagnostic imaging, Radiopharmaceuticals/chemistry, Tomography, X-Ray Computed
Pubmed
Web of science
Create date
20/08/2017 18:51
Last modification date
20/08/2019 16:21
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