Commentary on: "The contribution of tissue-specific BMI-associated gene sets to cardiometabolic disease risk: a Mendelian randomization study".

Details

Serval ID
serval:BIB_F4AADCF992A5
Type
Article: article from journal or magazin.
Publication sub-type
Letter (letter): Communication to the publisher.
Collection
Publications
Institution
Title
Commentary on: "The contribution of tissue-specific BMI-associated gene sets to cardiometabolic disease risk: a Mendelian randomization study".
Journal
International journal of epidemiology
Author(s)
Kutalik Z.
ISSN
1464-3685 (Electronic)
ISSN-L
0300-5771
Publication state
Published
Issued date
01/08/2020
Peer-reviewed
Oui
Volume
49
Number
4
Pages
1257-1258
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Mendelian randomization is an instrumental variable technique to estimate the causal effects of risk factors on an outcome. Each genetic variant fulfilling certain conditions can be used as an instrument and leveraged to provide such an estimate. In cases where distinct processes underlie a causal relationship, the resulting estimates may differ substantially, and hence such discrepancies could be detected.
An article in this issue, by Verkouter et al., proposes an approach to define groups of instruments a priori—based on their potential tissue-specific mechanism—and examine whether tissue-grouped causal effects show evidence of divergent mechanisms
Pubmed
Create date
28/05/2020 11:13
Last modification date
23/11/2020 7:24
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