Involvement of caveolin-1 in neurovascular unit remodeling after stroke: Effects on neovascularization and astrogliosis.

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Ressource 1Download: Blochet-2018 author copy.pdf (561.52 [Ko])
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Version: Author's accepted manuscript
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Serval ID
serval:BIB_F48E14390C89
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Involvement of caveolin-1 in neurovascular unit remodeling after stroke: Effects on neovascularization and astrogliosis.
Journal
Journal of cerebral blood flow and metabolism
Author(s)
Blochet C., Buscemi L., Clément T., Gehri S., Badaut J., Hirt L.
ISSN
1559-7016 (Electronic)
ISSN-L
0271-678X
Publication state
Published
Issued date
01/2020
Peer-reviewed
Oui
Volume
40
Number
1
Pages
163-176
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Complex cellular and molecular events occur in the neurovascular unit after stroke, such as blood-brain barrier (BBB) dysfunction and inflammation that contribute to neuronal death, neurological deterioration and mortality. Caveolin-1 (Cav-1) has distinct physiological functions such as caveolae formation associated with endocytosis and transcytosis as well as in signaling pathways. Cav-1 has been proposed to be involved in BBB dysfunction after brain injury; however, its precise role is poorly understood. The goal of this study was to characterize the expression and effect of Cav-1 deletion on outcome in the first week in a transient Middle Cerebral Artery Occlusion stroke model. We found increased Cav-1 expression in new blood vessels in the lesion and in reactive astrocytes in the peri-lesion areas. In Cav-1 KO mice, the lesion volume was larger and the behavioral outcome worse than in WT mice. Cav-1 KO mice exhibited reduced neovascularization and modified astrogliosis, without formation of a proper glial scar around the lesion at three days post injury, coinciding with aggravated outcomes. Altogether, these results point towards a potential protective role of endogenous Cav-1 in the first days after ischemia by promoting neovascularization, astrogliosis and scar formation.
Keywords
Caveolin-1, astrogliosis, ischemic stroke, neovascularization, neuroprotection
Pubmed
Web of science
Create date
05/11/2018 8:50
Last modification date
08/05/2020 5:19
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