Hepatocellular carcinoma abutting large vessels: comparison of four percutaneous ablation systems.

Details

Serval ID
serval:BIB_F48CDF61B4A4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Hepatocellular carcinoma abutting large vessels: comparison of four percutaneous ablation systems.
Journal
International journal of hyperthermia
Author(s)
Loriaud A., Denys A., Seror O., Vietti Violi N., Digklia A., Duran R., Trillaud H., Hocquelet A.
ISSN
1464-5157 (Electronic)
ISSN-L
0265-6736
Publication state
Published
Issued date
12/2018
Peer-reviewed
Oui
Volume
34
Number
8
Pages
1171-1178
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Multicenter Study
Publication Status: ppublish
Abstract
To compare overall local tumour progression (OLTP), defined as the failure of primary ablation or local tumour progression, with single applicator monopolar radiofrequency ablation (RFA), microwave ablation (MWA), cluster-RFA and multi-bipolar radiofrequency (mbpRFA) in the treatment of hepatocellular carcinoma (HCC) ≤ 5 cm abutting large vessels (≥3 mm).
This multicenter, retrospective, per-nodule study was performed from 2007 to 2015. The study was approved by the ethics review board, and informed consent was waived. A total of 160/914 HCC nodules treated by thermal ablation and abutting large vessels (40 per treatment group) treated by monopolar RFA, MWA, cluster-RFA or mbpRFA were matched for tumour size, alpha-feto-protein level and vessel size. OLTP rates were compared by the log-rank test and the multivariate Cox model after matching.
No differences were observed in tumour size, vessel size or alpha-feto-protein levels among the three groups (p = 1). The cumulative 4-year OLTP rates following monopolar RFA, cluster-RFA, multi-bipolar RFA and MWA were 50.5%, 16.3%, 16.3% and 44.2%, respectively (p = 0.036). On multivariate Cox regression, vessel size ≥10 mm, monopolar RFA and MWA were independent risk factors of OLTP compared to cluster-RFA or mbpRFA.
Multi-applicator RFA provides better local tumour control in HCC abutting large vessels than single-applicator techniques (monopolar RFA or MWA).
Keywords
Aged, Blood Vessels, Carcinoma, Hepatocellular/blood, Carcinoma, Hepatocellular/pathology, Carcinoma, Hepatocellular/surgery, Catheter Ablation/instrumentation, Catheter Ablation/methods, Disease Progression, Female, Humans, Liver Neoplasms/blood, Liver Neoplasms/pathology, Liver Neoplasms/surgery, Male, Microwaves/therapeutic use, Middle Aged, Tumor Burden, alpha-Fetoproteins/analysis, Ablation technique, blood vessels, carcinoma, hepatocellular, interventional, microwaves, radiography
Pubmed
Web of science
Open Access
Yes
Create date
01/03/2018 16:58
Last modification date
06/05/2020 15:58
Usage data