Beta-adrenergic blockade and intravenous nutrient-induced thermogenesis in lean and obese women.

Details

Serval ID
serval:BIB_F47623A93C69
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Beta-adrenergic blockade and intravenous nutrient-induced thermogenesis in lean and obese women.
Journal
American Journal of Physiology. Endocrinology and Metabolism
Author(s)
Vernet O., Nacht C.A., Christin L., Schutz Y., Danforth E., Jequier E.
ISSN
0193-1849 (Print)
ISSN-L
0002-9513
Publication state
Published
Issued date
1987
Volume
253
Number
1 Pt 1
Pages
E65-E71
Language
english
Abstract
Continuous respiratory exchange measurements were performed in nine obese and eight lean women for 1 h before, 3 h during, and 1 h after the intravenous administration of a nutrient mixture infused at twice the postabsorptive resting energy expenditure (REE). This experiment was conducted without or with beta-adrenergic blockade (iv propranolol). Propranolol administration did not change the postabsorptive REE [i.e., 1.03 +/- 0.07 before vs. 1.01 +/- 0.02 kcal/min after administration in lean women and 1.16 +/- 0.04 vs. 1.15 +/- 0.03 kcal/min (NS) in obese women]. The mean overall thermogenic response expressed as a percentage of the infused energy was similar in both groups and was not significantly blunted after propranolol infusion [6.9 +/- 0.4 vs. 5.9 +/- 0.6% in the lean women and 7.5 +/- 0.5 vs. 7.1 +/- 0.6% (NS) in the obese women]. During beta-adrenergic blockade the rate of lipid oxidation decreased in the lean group but was unchanged in the obese group and the glycemic response to nutrient administration was significantly higher in both groups than without propranolol. It is concluded that beta-adrenergic blockade has no effect on REE and on intravenous nutrient-induced thermogenesis in both lean and obese women.
Keywords
Adrenergic alpha-Antagonists/pharmacology, Blood Glucose/analysis, Blood Pressure, Body Temperature Regulation/drug effects, Energy Metabolism, Female, Heart Rate, Humans, Injections, Intravenous, Nutritional Physiological Phenomena, Obesity/blood, Obesity/metabolism, Respiration, Rest
Pubmed
Web of science
Create date
21/01/2008 14:08
Last modification date
20/08/2019 17:21
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