Utilite de l'enregistrement ambulatoire de la pression arterielle dans les essais therapeutiques de medicaments antihypertenseurs. [Usefulness of ambulatory registration of arterial pressure in therapeutic trials of antihypertensive agents]

Details

Serval ID
serval:BIB_F43E45281E16
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Utilite de l'enregistrement ambulatoire de la pression arterielle dans les essais therapeutiques de medicaments antihypertenseurs. [Usefulness of ambulatory registration of arterial pressure in therapeutic trials of antihypertensive agents]
Journal
Schweizerische Medizinische Wochenschrift
Author(s)
Rion  F., Waeber  B., Graf  H. J., Jaussi  A., Porchet  M., Brunner  H. R.
ISSN
0036-7672 (Print)
Publication state
Published
Issued date
12/1985
Volume
115
Number
50
Pages
1829-31
Notes
Clinical Trial
Comparative Study
English Abstract
Journal Article
Randomized Controlled Trial --- Old month value: Dec 14
Abstract
In the context of a controlled antihypertensive drug trial, blood pressure readings obtained by the physician in his office were compared with ambulatory blood pressures recorded with the semi-automatic Remler device. The beta-adrenoceptor blocking agent timolol or methyldopa were administered in double-blind fashion to 30 patients with uncomplicated essential hypertension. All exhibited a diastolic office blood pressure of greater than 95 mm Hg at the end of a 4-week placebo period. All patients then received a combination of hydrochlorothiazide (25 mg/d) and amiloride (2.5 mg/d). After 4 weeks of diuretic therapy, timolol (10 mg/d, n = 14) or methyldopa (250 mg/d, n = 16) were added randomly for 6 weeks. The dose of all antihypertensive agents was doubled after 2 weeks of therapy with diuretics combined with timolol (n = 7) or methyldopa (n = 16) because of the persistence of diastolic blood pressure levels of greater than 90 mm Hg at the office. When assessed in the office, the antihypertensive effect of timolol and methyldopa was similar. During ambulatory blood pressure monitoring, however, pressure levels tended to be lower in the patients given timolol (p less than 0.05 for the diastolic). These data show that ambulatory blood pressure monitoring may be very useful in comparing the antihypertensive efficacy of different drugs.
Keywords
Adult Aged *Ambulatory Care Amiloride/administration & dosage Antihypertensive Agents/*therapeutic use Blood Pressure Determination/*methods Double-Blind Method Drug Combinations Female Humans Hydrochlorothiazide/administration & dosage Male Methyldopa/therapeutic use Middle Aged *Private Practice Timolol/therapeutic use
Pubmed
Web of science
Create date
28/01/2008 12:54
Last modification date
20/08/2019 17:21
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