Endurance training enhances vasodilation induced by nitric oxide in human skin

Details

Serval ID
serval:BIB_F426DBFB1659
Type
Article: article from journal or magazin.
Collection
Publications
Title
Endurance training enhances vasodilation induced by nitric oxide in human skin
Journal
Journal of Investigative Dermatology
Author(s)
Boegli  Y., Gremion  G., Golay  S., Kubli  S., Liaudet  L., Leyvraz  P. F., Waeber  B., Feihl  F.
ISSN
0022-202X (Print)
Publication state
Published
Issued date
11/2003
Volume
121
Number
5
Pages
1197-204
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Abstract
Endurance training modifies the thermoregulatory control of skin blood flow, as manifested by a greater augmentation of skin perfusion for the same increase in core temperature in athletes, in comparison with sedentary subjects. In this study, we tested the hypothesis that a component of this adaptation might reside in a higher ability of cutaneous blood vessels to respond to vasodilatory stimuli. We recruited healthy nonsmoking males, either endurance trained or sedentary, in two different age ranges (18-35 y and >50 y). Skin blood flow was measured in the forearm skin, using a laser Doppler imager, allowing to record the vasodilatory responses to the following stimuli: iontophoresis of acetylcholine (an endothelium-dependent vasodilator), iontophoresis of sodium nitroprusside (a nitric oxide donor), and release of a temporary interruption of arterial inflow (reactive hyperemia). There was no effect of training on reactive hyperemia or the response to acetylcholine. In contrast, the increase in perfusion following the iontophoresis of sodium nitroprusside, expressed in perfusion units, was larger in trained than in sedentary subjects (younger: 398 +/- 54 vs 350 +/- 87, p < 0.05; older 339 +/- 72 vs 307 +/- 66, p < 0.05). In conclusion, endurance training enhances the vasodilatory effects of nitric oxide in the human dermal microcirculation, at least in forearm skin. These observations have considerable physiologic interest in view of recent data indicating that nitric oxide mediates in part the cutaneous vasodilation induced by heat stress in humans. Therefore, the augmentation of nitric oxide bioactivity in the dermal microcirculation might be one mechanism whereby endurance training modifies the thermoregulatory control of skin blood flow.
Keywords
Adolescent Adult Age Factors Aged Animals Humans Male Microcirculation Middle Aged Nitric Oxide/*physiology Nitroprusside/pharmacology Oxygen Consumption *Physical Endurance Skin/*blood supply Vasodilation/*drug effects
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 10:38
Last modification date
09/05/2019 3:28
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