Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.

Stolk, L.; Perry, J.R.; Chasman, D.I.; He, C.; Mangino, M.; Sulem, P.; Barbalic, M.; Broer, L.; Byrne, E.M.; Ernst, F.; Esko, T.; Franceschini, N.; Gudbjartsson, D.F.; Hottenga, J.J.; Kraft, P.; McArdle, P.F.; Porcu, E.; Shin, S.Y.; Smith, A.V.; van Wingerden, S.; Zhai, G.; Zhuang, W.V.; Albrecht, E.; Alizadeh, B.Z.; Aspelund, T.; Bandinelli, S.; Lauc, L.B.; Beckmann, J.S.; Boban, M.; Boerwinkle, E.; Broekmans, F.J.; Burri, A.; Campbell, H.; Chanock, S.J.; Chen, C.; Cornelis, M.C.; Corre, T.; Coviello, A.D.; d'Adamo, P.; Davies, G.; de Faire, U.; de Geus, E.J.; Deary, I.J.; Dedoussis, G.V.; Deloukas, P.; Ebrahim, S.; Eiriksdottir, G.; Emilsson, V.; Eriksson, J.G.; Fauser, B.C.; Ferreli, L.; Ferrucci, L.; Fischer, K.; Folsom, A.R.; Garcia, M.E.; Gasparini, P.; Gieger, C.; Glazer, N.; Grobbee, D.E.; Hall, P.; Haller, T.; Hankinson, S.E.; Hass, M.; Hayward, C.; Heath, A.C.; Hofman, A.; Ingelsson, E.; Janssens, A.C.; Johnson, A.D.; Karasik, D.; Kardia, S.L.; Keyzer, J.; Kiel, D.P.; Kolcic, I.; Kutalik, Z.; Lahti, J.; Lai, S.; Laisk, T.; Laven, J.S.; Lawlor, D.A.; Liu, J.; Lopez, L.M.; Louwers, Y.V.; Magnusson, P.K.; Marongiu, M.; Martin, N.G.; Klaric, I.M.; Masciullo, C.; McKnight, B.; Medland, S.E.; Melzer, D.; Mooser, V.; Navarro, P.; Newman, A.B.; Nyholt, D.R.; Onland-Moret, N.C.; Palotie, A.; Paré, G.; Parker, A.N.; Pedersen, N.L.; Peeters, P.H.; Pistis, G.; Plump, A.S.; Polasek, O.; Pop, V.J.; Psaty, B.M.; Räikkönen, K.; Rehnberg, E.; Rotter, J.I.; Rudan, I.; Sala, C.; Salumets, A.; Scuteri, A.; Singleton, A.; Smith, J.A.; Snieder, H.; Soranzo, N.; Stacey, S.N.; Starr, J.M.; Stathopoulou, M.G.; Stirrups, K.; Stolk, R.P.; Styrkarsdottir, U.; Sun, Y.V.; Tenesa, A.; Thorand, B.; Toniolo, D.; Tryggvadottir, L.; Tsui, K.; Ulivi, S.; van Dam, R.M.; van der Schouw, Y.T.; van Gils, C.H.; van Nierop, P.; Vink, J.M.; Visscher, P.M.; Voorhuis, M.; Waeber, G.; Wallaschofski, H.; Wichmann, H.E.; Widen, E.; Wijnands-van Gent, C.J.; Willemsen, G.; Wilson, J.F.; Wolffenbuttel, B.H.; Wright, A.F.; Yerges-Armstrong, L.M.; Zemunik, T.; Zgaga, L.; Zillikens, M.C.; Zygmunt, M.; Arnold, A.M.; Boomsma, D.I.; Buring, J.E.; Crisponi, L.; Demerath, E.W.; Gudnason, V.; Harris, T.B.; Hu, F.B.; Hunter, D.J.; Launer, L.J.; Metspalu, A.; Montgomery, G.W.; Oostra, B.A.; Ridker, P.M.; Sanna, S.; Schlessinger, D.; Spector, T.D.; Stefansson, K.; Streeten, E.A.; Thorsteinsdottir, U.; Uda, M.; Uitterlinden, A.G.; van Duijn, C.M.; Völzke, H.; Murray, A.; Murabito, J.M.; Visser, J.A.; Lunetta, K.L.

doi:10.1038/ng.1051

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.

Details

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Serval ID

serval:BIB_F3EFAC2A846A

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.

Journal

Nature Genetics

Author(s)

Stolk L., Perry J.R., Chasman D.I., He C., Mangino M., Sulem P., Barbalic M., Broer L., Byrne E.M., Ernst F., Esko T., Franceschini N., Gudbjartsson D.F., Hottenga J.J., Kraft P., McArdle P.F., Porcu E., Shin S.Y., Smith A.V., van Wingerden S., Zhai G., Zhuang W.V., Albrecht E., Alizadeh B.Z., Aspelund T., Bandinelli S., Lauc L.B., Beckmann J.S., Boban M., Boerwinkle E., Broekmans F.J., Burri A., Campbell H., Chanock S.J., Chen C., Cornelis M.C., Corre T., Coviello A.D., d'Adamo P., Davies G., de Faire U., de Geus E.J., Deary I.J., Dedoussis G.V., Deloukas P., Ebrahim S., Eiriksdottir G., Emilsson V., Eriksson J.G., Fauser B.C., Ferreli L., Ferrucci L., Fischer K., Folsom A.R., Garcia M.E., Gasparini P., Gieger C., Glazer N., Grobbee D.E., Hall P., Haller T., Hankinson S.E., Hass M., Hayward C., Heath A.C., Hofman A., Ingelsson E., Janssens A.C., Johnson A.D., Karasik D., Kardia S.L., Keyzer J., Kiel D.P., Kolcic I., Kutalik Z., Lahti J., Lai S., Laisk T., Laven J.S., Lawlor D.A., Liu J., Lopez L.M., Louwers Y.V., Magnusson P.K., Marongiu M., Martin N.G., Klaric I.M., Masciullo C., McKnight B., Medland S.E., Melzer D., Mooser V., Navarro P., Newman A.B., Nyholt D.R., Onland-Moret N.C., Palotie A., Paré G., Parker A.N., Pedersen N.L., Peeters P.H., Pistis G., Plump A.S., Polasek O., Pop V.J., Psaty B.M., Räikkönen K., Rehnberg E., Rotter J.I., Rudan I., Sala C., Salumets A., Scuteri A., Singleton A., Smith J.A., Snieder H., Soranzo N., Stacey S.N., Starr J.M., Stathopoulou M.G., Stirrups K., Stolk R.P., Styrkarsdottir U., Sun Y.V., Tenesa A., Thorand B., Toniolo D., Tryggvadottir L., Tsui K., Ulivi S., van Dam R.M., van der Schouw Y.T., van Gils C.H., van Nierop P., Vink J.M., Visscher P.M., Voorhuis M., Waeber G., Wallaschofski H., Wichmann H.E., Widen E., Wijnands-van Gent C.J., Willemsen G., Wilson J.F., Wolffenbuttel B.H., Wright A.F., Yerges-Armstrong L.M., Zemunik T., Zgaga L., Zillikens M.C., Zygmunt M., Arnold A.M., Boomsma D.I., Buring J.E., Crisponi L., Demerath E.W., Gudnason V., Harris T.B., Hu F.B., Hunter D.J., Launer L.J., Metspalu A., Montgomery G.W., Oostra B.A., Ridker P.M., Sanna S., Schlessinger D., Spector T.D., Stefansson K., Streeten E.A., Thorsteinsdottir U., Uda M., Uitterlinden A.G., van Duijn C.M., Völzke H., Murray A., Murabito J.M., Visser J.A., Lunetta K.L.

Working group(s)

Study T.L.

ISSN

1546-1718 (Electronic)

ISSN-L

1061-4036

Publication state

Published

Issued date

2012

Volume

Number

Pages

260-268

Language

english

Notes

Publication types: Journal ArticlePublication Status: epublish

Abstract

To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 × 10(-8)). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-κB signaling and mitochondrial dysfunction as biological processes related to timing of menopause.

URN

urn:nbn:ch:serval-BIB_F3EFAC2A846A2

OAI-PMH

oai:serval.unil.ch:BIB_F3EFAC2A846A

DOI

10.1038/ng.1051

Pubmed

22267201

Web of science

000300843600010

Create date

04/04/2012 14:50