Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.

Details

Serval ID
serval:BIB_F3EFAC2A846A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
Journal
Nature Genetics
Author(s)
Stolk L., Perry J.R., Chasman D.I., He C., Mangino M., Sulem P., Barbalic M., Broer L., Byrne E.M., Ernst F., Esko T., Franceschini N., Gudbjartsson D.F., Hottenga J.J., Kraft P., McArdle P.F., Porcu E., Shin S.Y., Smith A.V., van Wingerden S., Zhai G., Zhuang W.V., Albrecht E., Alizadeh B.Z., Aspelund T., Bandinelli S., Lauc L.B., Beckmann J.S., Boban M., Boerwinkle E., Broekmans F.J., Burri A., Campbell H., Chanock S.J., Chen C., Cornelis M.C., Corre T., Coviello A.D., d'Adamo P., Davies G., de Faire U., de Geus E.J., Deary I.J., Dedoussis G.V., Deloukas P., Ebrahim S., Eiriksdottir G., Emilsson V., Eriksson J.G., Fauser B.C., Ferreli L., Ferrucci L., Fischer K., Folsom A.R., Garcia M.E., Gasparini P., Gieger C., Glazer N., Grobbee D.E., Hall P., Haller T., Hankinson S.E., Hass M., Hayward C., Heath A.C., Hofman A., Ingelsson E., Janssens A.C., Johnson A.D., Karasik D., Kardia S.L., Keyzer J., Kiel D.P., Kolcic I., Kutalik Z., Lahti J., Lai S., Laisk T., Laven J.S., Lawlor D.A., Liu J., Lopez L.M., Louwers Y.V., Magnusson P.K., Marongiu M., Martin N.G., Klaric I.M., Masciullo C., McKnight B., Medland S.E., Melzer D., Mooser V., Navarro P., Newman A.B., Nyholt D.R., Onland-Moret N.C., Palotie A., Paré G., Parker A.N., Pedersen N.L., Peeters P.H., Pistis G., Plump A.S., Polasek O., Pop V.J., Psaty B.M., Räikkönen K., Rehnberg E., Rotter J.I., Rudan I., Sala C., Salumets A., Scuteri A., Singleton A., Smith J.A., Snieder H., Soranzo N., Stacey S.N., Starr J.M., Stathopoulou M.G., Stirrups K., Stolk R.P., Styrkarsdottir U., Sun Y.V., Tenesa A., Thorand B., Toniolo D., Tryggvadottir L., Tsui K., Ulivi S., van Dam R.M., van der Schouw Y.T., van Gils C.H., van Nierop P., Vink J.M., Visscher P.M., Voorhuis M., Waeber G., Wallaschofski H., Wichmann H.E., Widen E., Wijnands-van Gent C.J., Willemsen G., Wilson J.F., Wolffenbuttel B.H., Wright A.F., Yerges-Armstrong L.M., Zemunik T., Zgaga L., Zillikens M.C., Zygmunt M., Arnold A.M., Boomsma D.I., Buring J.E., Crisponi L., Demerath E.W., Gudnason V., Harris T.B., Hu F.B., Hunter D.J., Launer L.J., Metspalu A., Montgomery G.W., Oostra B.A., Ridker P.M., Sanna S., Schlessinger D., Spector T.D., Stefansson K., Streeten E.A., Thorsteinsdottir U., Uda M., Uitterlinden A.G., van Duijn C.M., Völzke H., Murray A., Murabito J.M., Visser J.A., Lunetta K.L.
Working group(s)
Study T.L.
ISSN
1546-1718 (Electronic)
ISSN-L
1061-4036
Publication state
Published
Issued date
2012
Volume
44
Number
3
Pages
260-268
Language
english
Notes
Publication types: Journal ArticlePublication Status: epublish
Abstract
To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 × 10(-8)). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-κB signaling and mitochondrial dysfunction as biological processes related to timing of menopause.
Pubmed
Web of science
Create date
04/04/2012 15:50
Last modification date
20/08/2019 17:20
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