Mapping and characterization of positive and negative BOLD responses to visual stimulation in multiple brain regions at 7T.

Details

Serval ID
serval:BIB_F389BD3647B9
Type
Article: article from journal or magazin.
Collection
Publications
Title
Mapping and characterization of positive and negative BOLD responses to visual stimulation in multiple brain regions at 7T.
Journal
Human brain mapping
Author(s)
Jorge J., Figueiredo P., Gruetter R., van der Zwaag W.
ISSN
1097-0193 (Electronic)
ISSN-L
1065-9471
Publication state
Published
Issued date
06/2018
Peer-reviewed
Oui
Volume
39
Number
6
Pages
2426-2441
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
External stimuli and tasks often elicit negative BOLD responses in various brain regions, and growing experimental evidence supports that these phenomena are functionally meaningful. In this work, the high sensitivity available at 7T was explored to map and characterize both positive (PBRs) and negative BOLD responses (NBRs) to visual checkerboard stimulation, occurring in various brain regions within and beyond the visual cortex. Recently-proposed accelerated fMRI techniques were employed for data acquisition, and procedures for exclusion of large draining vein contributions, together with ICA-assisted denoising, were included in the analysis to improve response estimation. Besides the visual cortex, significant PBRs were found in the lateral geniculate nucleus and superior colliculus, as well as the pre-central sulcus; in these regions, response durations increased monotonically with stimulus duration, in tight covariation with the visual PBR duration. Significant NBRs were found in the visual cortex, auditory cortex, default-mode network (DMN) and superior parietal lobule; NBR durations also tended to increase with stimulus duration, but were significantly less sustained than the visual PBR, especially for the DMN and superior parietal lobule. Responses in visual and auditory cortex were further studied for checkerboard contrast dependence, and their amplitudes were found to increase monotonically with contrast, linearly correlated with the visual PBR amplitude. Overall, these findings suggest the presence of dynamic neuronal interactions across multiple brain regions, sensitive to stimulus intensity and duration, and demonstrate the richness of information obtainable when jointly mapping positive and negative BOLD responses at a whole-brain scale, with ultra-high field fMRI.
Keywords
Adult, Brain/blood supply, Brain/diagnostic imaging, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Linear Models, Magnetic Resonance Imaging, Male, Oxygen/blood, Photic Stimulation, Young Adult, ICA denoising, draining veins, fMRI, multisensory, negative BOLD, visual stimulation
Pubmed
Web of science
Create date
15/04/2019 9:05
Last modification date
20/08/2019 17:20
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