Regulation of renin secretion in conscious adrenalectomized rats with glucocorticoid-induced hypertension

Details

Serval ID
serval:BIB_F37FF9B9080A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Regulation of renin secretion in conscious adrenalectomized rats with glucocorticoid-induced hypertension
Journal
Archives Internationales de Pharmacodynamie et de Therapie
Author(s)
Burris  J. F., Waeber  B., Nussberger  J., Brunner  H. R.
ISSN
0767-3981
0301-4533 (Print)
Publication state
Published
Issued date
04/1986
Volume
280
Number
2
Pages
292-301
Notes
Journal Article --- Old month value: Apr
Abstract
The effect of adrenalectomy on renin secretion was investigated in conscious rats with glucocorticoid-induced hypertension. Adrenalectomized and sham-operated rats were made hypertensive with methylprednisolone acetate (20 mg/kg s.c. once/week X 2 weeks) supplemented with deoxycorticosterone pivalate (10 mg/kg s.c. once/week X 2 weeks). During the 2 week developmental phase of hypertension, tap water or isotonic saline was given as drinking fluid to respectively 10 and 13 adrenalectomized rats and 10 and 11 sham-operated rats. On the day of the acute administration of captopril or vehicle there was no significant difference in body weight, mean blood pressure, heart rate, serum electrolytes and plasma norepinephrine levels between the 4 groups of rats. Circulating epinephrine could not be detected in adrenalectomized rats. Plasma renin activity was markedly higher in adrenalectomized rats than in the sham-operated rats even after sodium supplementation. Captopril (10 mg/kg i.v.) produced no significant blood pressure lowering effect in rats given tap water to drink, either adrenalectomized (n = 11) or sham-operated (n = 10). These findings indicate that the activation of the renin-angiotensin system in adrenalectomized rats with glucocorticoid-induced hypertension is not directly mediated by the development of adrenal failure. They also show that the maintenance of high blood pressure in this form of experimental hypertension is not significantly enhanced when renin secretion is stimulated by adrenalectomy.
Keywords
*Adrenalectomy Animals Blood Pressure/drug effects Captopril/pharmacology Epinephrine/blood Glucocorticoids Hypertension/*chemically induced/physiopathology Male Norepinephrine/blood Rats Rats, Inbred Strains Renin/*secretion
Pubmed
Web of science
Create date
05/03/2008 17:41
Last modification date
20/08/2019 17:20
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