Left Ventricular Hypertrabeculation Is Not Associated With Cardiovascular Morbity or Mortality: Insights From the Eurocmr Registry

Details

Serval ID
serval:BIB_F3430F27078F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Left Ventricular Hypertrabeculation Is Not Associated With Cardiovascular Morbity or Mortality: Insights From the Eurocmr Registry
Journal
Frontiers in Cardiovascular Medicine
Author(s)
Zemrak Filip, Raisi-Estabragh Zahra, Khanji Mohammed Y., Mohiddin Saidi A., Bruder Oliver, Wagner Anja, Lombardi Massimo, Schwitter Juerg, van Rossum Albert C., Pilz Günter, Nothnagel Detlev, Steen Henning, Nagel Eike, Prasad Sanjay K., Deluigi Christina C., Dill Thorsten, Frank Herbert, Schneider Steffen, Mahrholdt Heiko, Petersen Steffen E.
ISSN
2297-055X
Publication state
Published
Issued date
22/09/2020
Volume
7
Pages
158
Language
english
Abstract
Aim: Left ventricular non-compaction (LVNC) is perceived as a rare high-risk cardiomyopathy characterized by excess left ventricular (LV) trabeculation. However, there is increasing evidence contesting the clinical significance of LV hyper-trabeculation and the existence of LVNC as a distinct cardiomyopathy. The aim of this study is to assess the association of LV trabeculation extent with cardiovascular morbidity and all-cause mortality in patients undergoing clinical cardiac magnetic resonance (CMR) scans across 57 European centers from the EuroCMR registry. Methods and Results: We studied 822 randomly selected cases from the EuroCMR registry. Image acquisition was according to international guidelines. We manually segmented images for LV chamber quantification and measurement of LV trabeculation (as per Petersen criteria). We report the association between LV trabeculation extent and important cardiovascular morbidities (stroke, atrial fibrillation, heart failure) and all-cause mortality prospectively recorded over 404 ± 82 days of follow-up. Maximal non-compaction to compaction ratio (NC/C) was mean (standard deviation) 1.81 ± 0.67, from these, 17% were above the threshold for hyper-trabeculation (NC/C > 2.3). LV trabeculation extent was not associated with increased risk of the defined outcomes (morbidities, mortality, LV CMR indices) in the whole cohort, or in sub-analyses of individuals without ischaemic heart disease, or those with NC/C > 2.3. Conclusion: Among 882 patients undergoing clinical CMR, excess LV trabeculation was not associated with a range of important cardiovascular morbidities or all-cause mortality over ~12 months of prospective follow-up. These findings suggest that LV hyper-trabeculation alone is not an indicator for worse cardiovascular prognosis.
Pubmed
Web of science
Open Access
Yes
Create date
20/10/2020 9:06
Last modification date
09/12/2020 7:24
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