Estrogen and progesterone receptors and pS2 and ERD5 antigens in gastric carcinomas from the European population.

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State: Public
Version: Final published version
License: All rights reserved
Serval ID
serval:BIB_F2F55AD48F31
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Estrogen and progesterone receptors and pS2 and ERD5 antigens in gastric carcinomas from the European population.
Journal
Modern pathology
Author(s)
Chaubert P., Bouzourene H., Saraga E.
ISSN
0893-3952 (Print)
ISSN-L
0893-3952
Publication state
Published
Issued date
03/1996
Peer-reviewed
Oui
Volume
9
Number
3
Pages
189-193
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
We examined immunohistochemically 50 gastric carcinomas from European patients for estrogen receptors, progesterone receptors, and hormone-receptor-related proteins pS2 and ERD5. Unlike gastric carcinomas from non-Europeans reported previously, the carcinomas of the present series were all negative for estrogen and progesterone receptors. One-half of them, however, expressed pS2, and three-fourths were positive for ERD5. pS2 expression was significantly more frequent in carcinomas of the diffuse type than in those of the intestinal type and in advanced carcinomas compared with early ones. Our results indicate that pS2 and ERD5 are estrogen independent in the stomach. The possibility that estrogen and progesterone receptor status could be different in gastric carcinomas from Occidental and non-Occidental patients is discussed.
Keywords
Biomarkers, Tumor, Carcinoma/chemistry, Carcinoma/epidemiology, Carcinoma/pathology, Europe/epidemiology, Humans, Immunohistochemistry, Neoplasm Proteins/analysis, Proteins/analysis, Receptors, Estrogen/analysis, Receptors, Progesterone/analysis, Stomach Neoplasms/chemistry, Stomach Neoplasms/epidemiology, Stomach Neoplasms/pathology, Trefoil Factor-1, Tumor Suppressor Proteins
Pubmed
Web of science
Create date
29/01/2008 19:35
Last modification date
16/07/2020 9:42
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