Identification of SARS-CoV-2-specific immune alterations in acutely ill patients.
Details
Serval ID
serval:BIB_F2EC576F0B51
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Identification of SARS-CoV-2-specific immune alterations in acutely ill patients.
Journal
The Journal of clinical investigation
ISSN
1558-8238 (Electronic)
ISSN-L
0021-9738
Publication state
Published
Issued date
15/04/2021
Peer-reviewed
Oui
Volume
131
Number
8
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Dysregulated immune profiles have been described in symptomatic patients infected with SARS-CoV-2. Whether the reported immune alterations are specific to SARS-CoV-2 infection or also triggered by other acute illnesses remains unclear. We performed flow cytometry analysis on fresh peripheral blood from a consecutive cohort of (a) patients hospitalized with acute SARS-CoV-2 infection, (b) patients of comparable age and sex hospitalized for another acute disease (SARS-CoV-2 negative), and (c) healthy controls. Using both data-driven and hypothesis-driven analyses, we found several dysregulations in immune cell subsets (e.g., decreased proportion of T cells) that were similarly associated with acute SARS-CoV-2 infection and non-COVID-19-related acute illnesses. In contrast, we identified specific differences in myeloid and lymphocyte subsets that were associated with SARS-CoV-2 status (e.g., elevated proportion of ICAM-1+ mature/activated neutrophils, ALCAM+ monocytes, and CD38+CD8+ T cells). A subset of SARS-CoV-2-specific immune alterations correlated with disease severity, disease outcome at 30 days, and mortality. Our data provide an understanding of the immune dysregulation specifically associated with SARS-CoV-2 infection among acute care hospitalized patients. Our study lays the foundation for the development of specific biomarkers to stratify SARS-CoV-2-positive patients at risk of unfavorable outcomes and to uncover candidate molecules to investigate from a therapeutic perspective.
Keywords
Acute Disease, Adult, Aged, B-Lymphocyte Subsets/immunology, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, COVID-19/epidemiology, COVID-19/immunology, COVID-19/mortality, Case-Control Studies, Cohort Studies, Female, Hospitalization, Humans, Leukocytes/classification, Leukocytes/immunology, Lymphocyte Activation, Male, Middle Aged, Models, Immunological, Monocytes/immunology, Multivariate Analysis, Neutrophils/immunology, Pandemics, Prognosis, Prospective Studies, Quebec/epidemiology, Risk Factors, SARS-CoV-2/immunology, Severity of Illness Index, Adaptive immunity, COVID-19, Innate immunity
Pubmed
Web of science
Publisher's website
Create date
09/05/2023 13:59
Last modification date
29/11/2024 14:39