Identification of SARS-CoV-2-specific immune alterations in acutely ill patients.

Details

Serval ID
serval:BIB_F2EC576F0B51
Type
Article: article from journal or magazin.
Collection
Publications
Title
Identification of SARS-CoV-2-specific immune alterations in acutely ill patients.
Journal
The Journal of clinical investigation
Author(s)
Rébillard R.M., Charabati M., Grasmuck C., Filali-Mouhim A., Tastet O., Brassard N., Daigneault A., Bourbonnière L., Anand S.P., Balthazard R., Beaudoin-Bussières G., Gasser R., Benlarbi M., Moratalla A.C., Solorio Y.C., Boutin M., Farzam-Kia N., Descôteaux-Dinelle J., Fournier A.P., Gowing E., Laumaea A., Jamann H., Lahav B., Goyette G., Lemaître F., Mamane V.H., Prévost J., Richard J., Thai K., Cailhier J.F., Chomont N., Finzi A., Chassé M., Durand M., Arbour N., Kaufmann D.E., Prat A., Larochelle C.
ISSN
1558-8238 (Electronic)
ISSN-L
0021-9738
Publication state
Published
Issued date
15/04/2021
Peer-reviewed
Oui
Volume
131
Number
8
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Dysregulated immune profiles have been described in symptomatic patients infected with SARS-CoV-2. Whether the reported immune alterations are specific to SARS-CoV-2 infection or also triggered by other acute illnesses remains unclear. We performed flow cytometry analysis on fresh peripheral blood from a consecutive cohort of (a) patients hospitalized with acute SARS-CoV-2 infection, (b) patients of comparable age and sex hospitalized for another acute disease (SARS-CoV-2 negative), and (c) healthy controls. Using both data-driven and hypothesis-driven analyses, we found several dysregulations in immune cell subsets (e.g., decreased proportion of T cells) that were similarly associated with acute SARS-CoV-2 infection and non-COVID-19-related acute illnesses. In contrast, we identified specific differences in myeloid and lymphocyte subsets that were associated with SARS-CoV-2 status (e.g., elevated proportion of ICAM-1+ mature/activated neutrophils, ALCAM+ monocytes, and CD38+CD8+ T cells). A subset of SARS-CoV-2-specific immune alterations correlated with disease severity, disease outcome at 30 days, and mortality. Our data provide an understanding of the immune dysregulation specifically associated with SARS-CoV-2 infection among acute care hospitalized patients. Our study lays the foundation for the development of specific biomarkers to stratify SARS-CoV-2-positive patients at risk of unfavorable outcomes and to uncover candidate molecules to investigate from a therapeutic perspective.
Keywords
Acute Disease, Adult, Aged, B-Lymphocyte Subsets/immunology, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, COVID-19/epidemiology, COVID-19/immunology, COVID-19/mortality, Case-Control Studies, Cohort Studies, Female, Hospitalization, Humans, Leukocytes/classification, Leukocytes/immunology, Lymphocyte Activation, Male, Middle Aged, Models, Immunological, Monocytes/immunology, Multivariate Analysis, Neutrophils/immunology, Pandemics, Prognosis, Prospective Studies, Quebec/epidemiology, Risk Factors, SARS-CoV-2/immunology, Severity of Illness Index, Adaptive immunity, COVID-19, Innate immunity
Pubmed
Web of science
Create date
09/05/2023 13:59
Last modification date
29/11/2024 14:39
Usage data