Genomics and evolution of Pneumocystis species.

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State: Public
Version: Author's accepted manuscript
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_F2A3AE952B9F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Genomics and evolution of Pneumocystis species.
Journal
Infection, genetics and evolution
Author(s)
Cissé O.H., Hauser P.M.
ISSN
1567-7257 (Electronic)
ISSN-L
1567-1348
Publication state
Published
Issued date
11/2018
Peer-reviewed
Oui
Volume
65
Pages
308-320
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
The genus Pneumocystis comprises highly diversified fungal species that cause severe pneumonia in individuals with a deficient immune system. These fungi infect exclusively mammals and present a strict host species specificity. These species have co-diverged with their hosts for long periods of time (> 100 MYA). Details of their biology and evolution are fragmentary mainly because of a lack of an established long-term culture system. Recent genomic advances have unlocked new areas of research and allow new hypotheses to be tested. We review here new findings of the genomic studies in relation with the evolutionary trajectory of these fungi and discuss the impact of genomic data analysis in the context of the population genetics. The combination of slow genome decay and limited expansion of specific gene families and introns reflect intimate interactions of these species with their hosts. The evolutionary adaptation of these organisms is profoundly influenced by their population structure, which in turn is determined by intrinsic features such as their self-fertilizing mating system, high host specificity, long generation times, and transmission mode. Essential key questions concerning their adaptation and speciation remain to be answered. The next cornerstone will consist in the establishment of a long-term culture system and genetic manipulation that should allow unravelling the driving forces of Pneumocystis species evolution.
Keywords
Biological Evolution, Genome, Fungal, Genomics, Humans, Pneumocystis/genetics, Pneumonia, Pneumocystis/microbiology
Pubmed
Web of science
Create date
04/09/2018 11:45
Last modification date
21/10/2019 14:19
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