Motor neuron syndrome and monoclonal IgM with antibody activity against gangliosides GM1 and GD1b
Details
Serval ID
serval:BIB_F23334366202
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Motor neuron syndrome and monoclonal IgM with antibody activity against gangliosides GM1 and GD1b
Journal
Annals of Neurology
ISSN
0364-5134 (Print)
Publication state
Published
Issued date
05/1988
Volume
23
Number
5
Pages
524-8
Notes
Case Reports
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Abstract
We demonstrated that an IgM M-protein from a patient with motor neuron syndrome had antibody activity against gangliosides GM1, GD1b, and asialo GM1. Studies with a sugar-binding lectin suggested that the epitope in the patient's M-IgM involved the Gal(beta 1-3) GalNAc moiety. Immunohistological techniques demonstrated staining of axons in the lumbar roots, granular cells, and white matter in the cerebellum by the patient's M-IgM. We propose that, in this case, an autoimmune mechanism of motor neuron syndrome associated with a monoclonal protein is most likely.
Keywords
Antibodies, Monoclonal/*blood/metabolism
Autoantibodies/*blood/metabolism
Brain/immunology
Female
G(M1) Ganglioside/*immunology
Gangliosides/*immunology
Humans
Middle Aged
Motor Neurons/*immunology
Neuromuscular Diseases/*immunology
Spinal Cord/immunology
Syndrome
Pubmed
Web of science
Create date
25/01/2008 12:46
Last modification date
20/08/2019 16:19