Surgical Management Evolution Between 2 Massive Burn Cases at 17-Year Interval: Contribution of Cell Therapies in Improving the Surgical Care.

Details

Serval ID
serval:BIB_F1F193A6A252
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Surgical Management Evolution Between 2 Massive Burn Cases at 17-Year Interval: Contribution of Cell Therapies in Improving the Surgical Care.
Journal
Cell transplantation
Author(s)
Monnier S., Abdel-Sayed P., Roessingh A.B., Hirt-Burri N., Chemali M., Applegate L.A., Raffoul W.
ISSN
1555-3892 (Electronic)
ISSN-L
0963-6897
Publication state
Published
Issued date
2020
Peer-reviewed
Oui
Volume
29
Pages
963689720973642
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
We report the cases of 2 patients admitted to our hospital at a 17-year interval, both with 90% total body surface area (TBSA) burns. These two young patients were in good health before their accident, but major differences in time of intensive care and hospitalization were observed: 162 versus 76 days in intensive care unit and 18 versus 9.5 months for hospitalization, respectively. We have analyzed the different parameters side-by-side during their medical care and we have identified that the overall improved outcomes are mainly due to a better adapted fluid reanimation in combination with the evolution of the surgical management to encompass allogenic cellular therapy (Biological Bandages). Indeed, autologous cell therapy using keratinocytes has been used for over 30 years in our hospital with the same technical specifications; however, we have integrated the Biological Bandages and routinely used them for burn patients to replace cadaver skin since the past 15 years. Thus, patient 1 versus patient 2 had, respectively, 83% versus 80% TBSA for autologous cells, and 0% versus 189% for allogenic cells. Notably, it was possible that patient 2 was able to recover ∼6% TBSA with the use of Biological Bandages, by stimulating intermediate burn zones toward a spontaneous healing without requiring further skin grafting (on abdomen and thighs). The body zones where Biological Bandages were not applied, such as the buttocks, progressed to deeper-stage burns. Despite inherent differences to patients at their admission and the complexity of severe burn care, the results of these two case reports suggest that integration of innovative allogenic cell therapies in the surgical care of burn patients could have major implications in the final outcome.
Keywords
Cell Biology, Transplantation, Biomedical Engineering, Biological Bandages, burn, cell therapy, cultured epithelial autograft, skin tissue engineering, wound care
Pubmed
Web of science
Open Access
Yes
Create date
26/05/2020 9:37
Last modification date
28/01/2021 7:25
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