Portal Vein Embolization before Right Hepatectomy: Improved Results Using n-Butyl-Cyanoacrylate Compared to Microparticles Plus Coils.

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Serval ID
serval:BIB_F1B6A1C97887
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Portal Vein Embolization before Right Hepatectomy: Improved Results Using n-Butyl-Cyanoacrylate Compared to Microparticles Plus Coils.
Journal
Cardiovascular and Interventional Radiology
Author(s)
Guiu B., Bize P., Gunthern D., Demartines N., Halkic N., Denys A.
ISSN
1432-086X (Electronic)
ISSN-L
0174-1551
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
36
Number
5
Pages
1306-1312
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
BACKGROUND: There is currently no consensus in the literature on which embolic agent induces the greatest degree of liver hypertrophy after portal vein embolization (PVE). Only experimental results in a pig model have demonstrated an advantage of n-butyl-cyanoacrylate (NBCA) over 3 other embolic materials (hydrophilic gel, small and large polyvinyl alcohol particles) for PVE. Therefore, the aim of this human study was to retrospectively compare the results of PVE using NBCA with those using spherical microparticles plus coils.
METHODS: A total of 34 patients underwent PVE using either NBCA (n = 20), or spherical microparticles plus coils (n = 14). PVE was decided according to preoperative volumetry on the basis of contrast-enhanced CT. Groups were compared for age, sex, volume of the left lobe before PVE and future remnant liver ratio (FRL) (volume of the left lobe/total liver volume - tumor volume). The primary end point was the increase in left lobe volume 1 month after PVE. Secondary end points were procedure complications and biological tolerance.
RESULTS: Both groups were similar in terms of age, sex ratio, left lobe volume, and FRL before PVE. NBCA induced a greater increase in volume after PVE than did microparticles plus coils (respectively, +74 ± 69 % and +23 ± 14 %, p < 0.05). The amount of contrast medium used for the procedure was significantly larger when microparticles and coils rather than NBCA were used (respectively, 264 ± 43 ml and 162 ± 34 ml, p < 0.01). The rate of PVE complications as well as the biological tolerance was similar in both groups.
CONCLUSION: NBCA seems more effective than spherical microparticles plus coils to induce left-lobe hypertrophy.
Pubmed
Web of science
Open Access
Yes
Create date
06/02/2013 10:15
Last modification date
01/10/2019 6:20
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