A Systematic Review of Discrete-Choice Experiments and Conjoint Analysis Studies in People with Multiple Sclerosis.

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State: Public
Version: Author's accepted manuscript
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Serval ID
serval:BIB_F1A6AB085AAD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A Systematic Review of Discrete-Choice Experiments and Conjoint Analysis Studies in People with Multiple Sclerosis.
Journal
The patient
Author(s)
Webb EJD, Meads D., Eskyte I., King N., Dracup N., Chataway J., Ford H.L., Marti J., Pavitt S.H., Schmierer K., Manzano A.
ISSN
1178-1661 (Electronic)
ISSN-L
1178-1653
Publication state
Published
Issued date
08/2018
Peer-reviewed
Oui
Volume
11
Number
4
Pages
391-402
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Multiple sclerosis (MS) is a chronic disabling, inflammatory, and degenerative disease of the central nervous system that, in most cases, requires long-term disease-modifying treatment (DMT). The drugs used vary in efficacy and adverse effect profiles. Several studies have used attribute-based stated-preference methods, primarily to investigate patient preferences for initiating or escalating DMT.
To conduct a systematic review of attribute-based stated-preference studies in people with MS to identify common methods employed and to assess study quality, with reference to the specific challenges of this disease area.
We conducted a systematic search for studies related to attribute-based stated-preference and MS in multiple databases, including Cochrane and MEDLINE. Studies were included if they were published in a peer-reviewed journal, were on the topic of MS, and used a survey methodology that measured stated preferences for attributes of a whole. Analysis was conducted using narrative synthesis and summary statistics. Study quality was judged against the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) conjoint analysis checklist.
We identified 16 relevant articles reporting 17 separate studies, all but one focusing on DMTs. Most studies were discrete-choice experiments. Study quality was generally high, but we recommend the following: (1) that consideration of sample sizes be improved, (2) that survey design choices be justified and documented, (3) that qualitative approaches for attribute and level selection be incorporated to better involve patients, and (4) that reporting of experimental practice be improved. The effects of DMTs on reproduction and the impact of how risk and uncertainty are presented were identified as neglected research topics. The ISPOR conjoint analysis checklist was found to be unsuitable for the assessment of study quality.
Attribute-based stated preference is a useful method with which to examine the preferences of people with MS in their choice of DMT. However, further research embracing the methodological recommendations identified, particularly greater use of qualitative methods in attribute development, is needed.
Keywords
Choice Behavior, Decision Making, Decision Support Techniques, Drug Administration Routes, Drug Administration Schedule, Humans, Immunosuppressive Agents/administration & dosage, Immunosuppressive Agents/adverse effects, Immunosuppressive Agents/therapeutic use, Multiple Sclerosis/drug therapy, Patient Preference, Qualitative Research, Quality of Life, Research Design
Pubmed
Web of science
Create date
22/01/2018 10:22
Last modification date
20/08/2019 16:19
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