Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses
Details
Serval ID
serval:BIB_F17F18FB5DD3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424
Publication state
Published
Issued date
10/2006
Peer-reviewed
Oui
Volume
103
Number
42
Pages
15535-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct 17
Research Support, Non-U.S. Gov't --- Old month value: Oct 17
Abstract
The reason why severe localized or systemic virus infections enhance and aggravate bacterial superinfection is poorly understood. Here we show that virus-induced IFN type I caused apoptosis in bone marrow granulocytes, drastically reduced granulocyte infiltrates at the site of bacterial superinfection, caused up to 1,000-fold higher bacterial titers in solid organs, and increased disease susceptibility. The finding that the innate antiviral immune response reduces the antibacterial granulocyte defense offers an explanation for enhanced susceptibility to bacterial superinfection during viral disease.
Keywords
Agranulocytosis
Animals
Apoptosis/physiology
Bacterial Infections/*immunology
Bone Marrow Cells/cytology/immunology
Disease Susceptibility/*immunology
Granulocytes/immunology
Immunity, Natural/*physiology
Interferon Type I/immunology
Listeria monocytogenes/immunology/pathogenicity
Liver/cytology
Lymphocytic Choriomeningitis
Lymphocytic choriomeningitis virus/immunology/pathogenicity
Mice
Mice, Inbred C57BL
Mice, Knockout
Receptor, Interferon alpha-beta/genetics/metabolism
Spleen/cytology
Staphylococcus aureus/immunology/pathogenicity
Superinfection/*immunology
Virus Diseases/*immunology
Pubmed
Web of science
Create date
11/02/2008 12:39
Last modification date
20/08/2019 16:18