Chronic rejection and chronic cyclosporin toxicity in renal allografts

Details

Serval ID
serval:BIB_F15653226CB8
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Chronic rejection and chronic cyclosporin toxicity in renal allografts
Journal
Immunology Today
Author(s)
Pascual  M., Swinford  R. D., Ingelfinger  J. R., Williams  W. W., Cosimi  A. B., Tolkoff-Rubin  N.
ISSN
0167-5699
Publication state
Published
Issued date
11/1998
Peer-reviewed
Oui
Volume
19
Number
11
Pages
514-9
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Nov
Abstract
Recent evidence indicates that growth factors are critically important in both chronic rejection and chronic cyclosporin A toxicity, suggesting that these two entities share a common pathophysiological pathway, leading to progressive allograft failure. Here, Manuel Pascual and colleagues discuss the relevance of growth factors to chronic allograft nephropathy, and the implications for therapy in view of the great choice of immunosuppressive drugs now available.
Keywords
Animals Blotting, Northern Cell Line Chronic Disease Cyclosporine/*adverse effects Dactinomycin/therapeutic use Graft Rejection/*etiology/prevention & control/therapy Growth Substances/immunology Humans Immunosuppressive Agents/*adverse effects Kidney Transplantation/*immunology Nucleic Acid Synthesis Inhibitors/therapeutic use RNA, Messenger Rats Transforming Growth Factor beta/immunology
Pubmed
Web of science
Create date
29/01/2008 13:52
Last modification date
20/08/2019 16:18
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