Quantitative trait loci associated with elevated thyroid-stimulating hormone in the Wistar-Kyoto rat.
Details
Serval ID
serval:BIB_F0D7E2987410
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Quantitative trait loci associated with elevated thyroid-stimulating hormone in the Wistar-Kyoto rat.
Journal
Endocrinology
ISSN
0013-7227 (Print)
ISSN-L
0013-7227
Publication state
Published
Issued date
02/2005
Peer-reviewed
Oui
Volume
146
Number
2
Pages
870-878
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Publication Status: ppublish
Abstract
Thyroid hormones are essential for the regulation of developmental and physiological processes. The genetic factors underlying naturally occurring variability in mammalian thyroid function are, however, only partially understood. Genetic control of thyroid function can be studied with animal models such as the inbred Wistar-Kyoto (WKY) rat strain. Previous studies established that WKY rats have elevated TSH, slightly elevated total T3, and normal total T4 levels compared with Wistar controls. The present study confirmed a persistent 24-h elevation of TSH in WKY rats compared with the Fisher 344 (F344) rat, another inbred strain. Acute T3 challenge (25 microg/100 g body weight ip) suppressed serum TSH and T4 levels in both strains. Quantitative trait locus analysis of elevated TSH in a reciprocally bred WKY x F344 F2 population identified one highly significant locus on chromosome 6 (LOD=11.7, TSH-1) and one suggestive locus on chromosome 5 (LOD=2.3, TSH-2). The confidence interval of TSH-1 contains the TSH receptor and type 2 deiodinase genes, and TSH-2 contains the type 1 deiodinase gene. The WKY alleles of each gene contain sequence alterations, but additional studies are indicated to identify the specific gene or genes responsible for altered regulation of the thyroid axis. These findings suggest that one or more genetic alterations within the TSH-1 locus significantly contribute to the altered thyroid function tests of the WKY rat.
Keywords
3' Untranslated Regions, Animals, Circadian Rhythm/physiology, Female, Genome, Iodide Peroxidase/genetics, Iodide Peroxidase/metabolism, Male, Nerve Tissue Proteins/genetics, Quantitative Trait Loci, Rats, Rats, Inbred F344, Rats, Inbred WKY/genetics, Thyrotropin/blood, Thyrotropin/genetics, Thyrotropin/metabolism, Thyroxine/blood, Thyroxine/metabolism, Triiodothyronine/blood, Triiodothyronine/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
30/12/2020 14:37
Last modification date
31/12/2020 6:26