Hyperacute graft rejection during heart transplantation for giant cell myocarditis: a case report.

Details

Serval ID
serval:BIB_F0B4388CC516
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Hyperacute graft rejection during heart transplantation for giant cell myocarditis: a case report.
Journal
Pathology, Research and Practice
Author(s)
Mutijima E., Delbecque K., Defraigne J.O., Bouillenne C., Damas P., Pierard L., Boniver J., de Leval L.
ISSN
1618-0631 (Electronic)
ISSN-L
0344-0338
Publication state
Published
Issued date
2010
Volume
206
Number
6
Pages
411-414
Language
english
Notes
Publication types: Case Reports ; Journal Article
Abstract
We report the case of a patient with giant cell myocarditis who was bridged to transplantation with mechanical circulatory support and developed a fatal perioperative hyperacute rejection. The patient had received abundant transfusions that had raised her anti-HLA antibody titers. The cross-match test was positive. No pre-transplantation immunosuppressive therapy had been administered given concomitant infection. The severity and acuteness of the rejection in this case likely reflect the combined effect of preformed anti-HLA antibodies in the context of an active organ-specific immune process at the time of transplantation. This case raises the questions of the need for intensive immunosuppressive therapy before transplantation in giant cell myocarditis and of the management of patients with positive cross-match in the context of a giant cell myocarditis.
Keywords
Acute Disease, Antibodies/blood, Antibodies/immunology, Blood Grouping and Crossmatching, Fatal Outcome, Female, Giant Cells/pathology, Graft Rejection/immunology, Graft Rejection/pathology, HLA Antigens/immunology, Heart Transplantation/immunology, Heart-Assist Devices, Humans, Middle Aged, Myocarditis/surgery
Pubmed
Create date
22/10/2010 10:49
Last modification date
03/03/2018 22:37
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