Characterization of PAN-1, a Carbapenem-Hydrolyzing Class B β-Lactamase From the Environmental Gram-Negative Pseudobacteriovorax antillogorgiicola.

Details

Serval ID
serval:BIB_F089B9A8D284
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Characterization of PAN-1, a Carbapenem-Hydrolyzing Class B β-Lactamase From the Environmental Gram-Negative Pseudobacteriovorax antillogorgiicola.
Journal
Frontiers in microbiology
Author(s)
Kieffer N., Poirel L., Fournier C., Haltli B., Kerr R., Nordmann P.
ISSN
1664-302X (Print)
ISSN-L
1664-302X
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
10
Pages
1673
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The gene encoding the metallo-β-lactamase (MβL) PAN-1 was identified in the genome of the environmental Gram-negative species Pseudobacteriovorax antillogorgiicola. PAN-1 shares 57% amino-acid identity with the acquired MβL SPM-1, its closest relative. Kinetic parameters performed on purified PAN-1 showed it displayed a hydrolytic activity toward most β-lactams including carbapenems but spared cefepime and aztreonam. These results further highlight that environmental bacterial species may be reservoirs of MβL encoding genes.
Keywords
PAN-1, Pseudobacteriovorax antillogorgiicola, carbapenemase, environment, metallo-β-lactamase
Pubmed
Web of science
Open Access
Yes
Create date
16/08/2019 21:47
Last modification date
21/08/2019 6:16
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