Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction.
Details
Serval ID
serval:BIB_F07838A72BCC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction.
Journal
Nature immunology
ISSN
1529-2908 (Print)
ISSN-L
1529-2908
Publication state
Published
Issued date
11/2007
Peer-reviewed
Oui
Volume
8
Number
11
Pages
1246-1254
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
In progressive viral infection, antiviral T cell function is impaired by poorly understood mechanisms. Here we report that the inhibitory immunoregulatory receptor CTLA-4 was selectively upregulated in human immunodeficiency virus (HIV)-specific CD4(+) T cells but not CD8(+) T cells in all categories of HIV-infected subjects evaluated, with the exception of rare people able to control viremia in the absence of antiretroviral therapy. CTLA-4 expression correlated positively with disease progression and negatively with the capacity of CD4(+) T cells to produce interleukin 2 in response to viral antigen. Most HIV-specific CD4(+) T cells coexpressed CTLA-4 and another inhibitory immunoregulatory receptor, PD-1. In vitro blockade of CTLA-4 augmented HIV-specific CD4(+) T cell function. These data, indicating a reversible immunoregulatory pathway selectively associated with CD4(+) T cell dysfunction, provide a potential target for immunotherapy in HIV-infected patients.
Keywords
Antigens, CD/immunology, Antigens, CD/metabolism, Antigens, Differentiation/metabolism, Apoptosis Regulatory Proteins/immunology, Apoptosis Regulatory Proteins/metabolism, CD4-Positive T-Lymphocytes/immunology, CD4-Positive T-Lymphocytes/metabolism, CD4-Positive T-Lymphocytes/virology, CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/metabolism, CD8-Positive T-Lymphocytes/virology, CTLA-4 Antigen, Cytokines/metabolism, Disease Progression, HIV Infections/immunology, HIV Infections/metabolism, Humans, Polymerase Chain Reaction, Programmed Cell Death 1 Receptor, Up-Regulation, Viral Load
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Create date
09/05/2023 14:00
Last modification date
29/11/2024 18:16