Evaluation of donor kidneys prior to transplantation: an update of current and emerging methods.

Details

Serval ID
serval:BIB_F04DBBDF5E3B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Evaluation of donor kidneys prior to transplantation: an update of current and emerging methods.
Journal
Transplant international
Author(s)
Moeckli B., Sun P., Lazeyras F., Morel P., Moll S., Pascual M., Bühler L.H.
ISSN
1432-2277 (Electronic)
ISSN-L
0934-0874
Publication state
Published
Issued date
05/2019
Peer-reviewed
Oui
Volume
32
Number
5
Pages
459-469
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The lack of suitable kidney donor organs has led to rising numbers of patients with end stage renal disease waiting for kidney transplantation. Despite decades of clinical experience and research, no evaluation process that can reliably predict the outcome of an organ has yet been established. This review is an overview of current methods and emerging techniques in the field of donor kidney evaluation prior to transplantation. Established techniques like histological evaluation, clinical scores, and machine perfusion systems offer relatively reliable predictions of delayed graft function but are unable to consistently predict graft survival. Emerging techniques including molecular biomarkers, new imaging technologies, and normothermic machine perfusion offer innovative approaches toward a more global evaluation of an organ with better outcome prediction and possibly even identification of targets for therapeutic interventions prior to transplantation. These techniques should be studied in randomized controlled trials to determine whether they can be safely used in routine clinical practice to ultimately reduce the discard rate and improve graft outcomes.
Keywords
biopsy, kidney transplantation, machine perfusion, magnetic resonance imaging, quality assessment, transcription analysis
Pubmed
Web of science
Create date
15/04/2019 8:19
Last modification date
20/08/2019 17:18
Usage data