Change in Emotional and Theory of Mind Processing in Borderline Personality Disorder: A Pilot Study.

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Version: Author's accepted manuscript
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Serval ID
serval:BIB_F027F2F4CB34
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Change in Emotional and Theory of Mind Processing in Borderline Personality Disorder: A Pilot Study.
Journal
The Journal of nervous and mental disease
Author(s)
Kramer U., Kolly S., Maillard P., Pascual-Leone A., Samson A.C., Schmitt R., Bernini A., Allenbach G., Charbon P., de Roten Y., Conus P., Despland J.N., Draganski B.
ISSN
1539-736X (Electronic)
ISSN-L
0022-3018
Publication state
Published
Issued date
12/2018
Peer-reviewed
Oui
Volume
206
Number
12
Pages
935-943
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Changes in emotional processing (EP) and in theory of mind (TOM) are central across treatment approaches for patients with borderline personality disorder (BPD). Although the assessment of EP relies on the observation of a patient's self-criticism in a two-chair dialogue, an individual's TOM assessments is made based on responses to humorous stimuli based on false beliefs. For this pilot study, we assessed eight patients with BPD before and after a 3-month-long psychiatric treatment, using functional magnetic resonance imaging and behavioral tasks. We observed arousal increase within the session of the two-chair dialogue (d = 0.36), paralleled by arousal decrease between sessions (d = 0.80). We found treatment-associated trends for neural activity reduction in brain areas central for EP and TOM. Our exploratory findings using an integrative assessment procedure of changes in EP and TOM point toward evidence for treatment effects at the brain systems level related to behavioral modulation.
Keywords
Borderline Personality Disorder/diagnostic imaging, Borderline Personality Disorder/physiopathology, Borderline Personality Disorder/psychology, Borderline Personality Disorder/therapy, Brain/diagnostic imaging, Brain/physiopathology, Emotional Intelligence/physiology, Emotions, Female, Functional Neuroimaging, Humans, Magnetic Resonance Imaging, Pilot Projects, Self Concept, Theory of Mind/physiology, Young Adult
Pubmed
Web of science
Create date
01/10/2018 9:11
Last modification date
08/05/2020 13:49
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