Relative roles of inhibin B and sex steroids in the negative feedback regulation of follicle-stimulating hormone in men across the full spectrum of seminiferous epithelium function.

Details

Serval ID
serval:BIB_EFFE15F6AD9A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Relative roles of inhibin B and sex steroids in the negative feedback regulation of follicle-stimulating hormone in men across the full spectrum of seminiferous epithelium function.
Journal
Journal of Clinical Endocrinology and Metabolism
Author(s)
Boepple P.A., Hayes F.J., Dwyer A.A., Raivio T., Lee H., Crowley W.F., Pitteloud N.
ISSN
0021-972X (Print)
ISSN-L
0021-972X
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
93
Number
5
Pages
1809-1814
Language
english
Notes
Publication types: Journal Article
Abstract
CONTEXT AND OBJECTIVE: Our aim was to explore the relative roles of gonadal sex steroids and inhibin B in the regulation of FSH across a spectrum of seminiferous epithelium function.
SUBJECTS: The study included three groups: group I, healthy men (n = 31); group II, men with idiopathic hypogonadotropic hypogonadism receiving pulsatile GnRH (n = 12) selected to represent a spectrum of seminiferous tubular development, testicular size, and baseline inhibin B levels; and group III, men with functional anorchia (n = 3) receiving testosterone replacement.
DESIGN: Subjects were studied before and after 3 d of acute sex steroid withdrawal.
SETTING: The study was conducted at the Mallinckrodt General Clinical Research Center of Massachusetts General Hospital.
INTERVENTIONS: Acute biochemical castration was achieved using high-dose ketoconazole (groups I and II) or withdrawal of androgen therapy (group III).
MAIN OUTCOME MEASURES: The relationship between FSH and inhibin B in both normal and castrate sex steroid milieu was measured.
RESULTS: In both normal and castrate sex steroid milieus, there was a negative relationship between inhibin B and FSH, best described by a logarithmic model. Acute biochemical castration resulted in the most dramatic increases in FSH in men with the lowest baseline inhibin B levels.
CONCLUSIONS: We came to the following conclusions: 1) in the human male, inhibin B is the principal gonadal feedback regulator of FSH secretion unless seminiferous tubular function is severely compromised, and a logarithmic model best describes this relationship; and 2) sex steroid inhibition of FSH secretion is most apparent when serum inhibin B levels fall well below the normal range.
Keywords
Adult, Feedback, Physiological, Follicle Stimulating Hormone/blood, Gonadal Steroid Hormones/physiology, Humans, Inhibins/blood, Inhibins/physiology, Male, Middle Aged, Seminiferous Epithelium/physiology
Pubmed
Open Access
Yes
Create date
03/12/2014 16:32
Last modification date
09/05/2019 3:14
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