Immunogenetics of invasive aspergillosis.

Details

Serval ID
serval:BIB_EFAD6C8AA3B3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Immunogenetics of invasive aspergillosis.
Journal
Medical mycology
Author(s)
Lamoth F., Rubino I., Bochud P.Y.
ISSN
1460-2709 (Electronic)
ISSN-L
1369-3786
Publication state
Published
Issued date
04/2011
Peer-reviewed
Oui
Volume
49 Suppl 1
Pages
S125-36
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Invasive aspergillosis is one of the most important infections in hematopoietic stem cell transplant recipients, with an incidence rate of 5-15% and an associated mortality of 30-60%. It remains unclear why certain patients develop invasive aspergillosis while others, undergoing identical transplant regimen and similar post transplant immunosuppression, do not. Over the last decade, pattern recognition receptors such as Toll-like receptors (TLRs) and the C-type lectin receptors (CLRs) have emerged as critical components of the innate immune system. By detecting specific molecular patterns from invading microbes and initiating inflammatory and subsequent adaptive immune responses, pattern recognition receptors are strategically located at the molecular interface of hosts and pathogens. Polymorphisms in pattern recognition receptors and downstream signaling molecules have been associated with increased or decreased susceptibility to infections, suggesting that their detection may have an increasing impact on the treatment and prevention of infectious diseases in the coming years. Infectious risk stratification may be particularly relevant for patients with hematologic malignancies, because of the high prevalence and severity of infections in this population. This review summarizes the innate immune mechanisms involved in Aspergillus fumigatus detection and the role of host genetic polymorphisms in susceptibility to invasive aspergillosis.
Keywords
Aspergillosis/genetics, Aspergillosis/immunology, Aspergillus/immunology, Aspergillus/pathogenicity, Hematopoietic Stem Cell Transplantation/adverse effects, Humans, Immunity, Innate, Immunogenetics, Immunosuppression/adverse effects, Lectins, C-Type/genetics, Lectins, C-Type/immunology, Polymorphism, Genetic, Receptors, Pattern Recognition/genetics, Receptors, Pattern Recognition/immunology, Risk Factors, Signal Transduction/immunology, Toll-Like Receptors/genetics, Toll-Like Receptors/immunology, Toll-Like Receptors/physiology
Pubmed
Web of science
Open Access
Yes
Create date
03/10/2019 17:11
Last modification date
04/10/2019 6:26
Usage data