Cerebello-thalamo-cortical Hyperconnectivity as a State-independent Functional Neural Signature for Psychosis Prediction and Characterization.

Details

Ressource 1Download: Cao, Chén et_al_2018_Nature Comm.pdf (1037.36 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_EF768B7EC3E1
Type
Article: article from journal or magazin.
Collection
Publications
Title
Cerebello-thalamo-cortical Hyperconnectivity as a State-independent Functional Neural Signature for Psychosis Prediction and Characterization.
Journal
Nature communications
Author(s)
Cao Hengyi, Chén Oliver Y, Chung Yoonho, Forsyth Jennifer K, McEwen Sarah C, Gee Dylan G, Bearden Carrie E, Addington Jean, Goodyear Bradley, Cadenhead Kristin S, Mirzakhanian Heline, Cornblatt Barbara A, Carrión Ricardo E, Mathalon Daniel H, McGlashan Thomas H, Perkins Diana O, Belger Aysenil, Seidman Larry J, Thermenos Heidi, Tsuang Ming T, van Erp Theo G M, Walker Elaine F, Hamann Stephan, Anticevic Alan, Woods Scott W, Cannon Tyrone D
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
21/09/2018
Peer-reviewed
Oui
Volume
9
Number
1
Pages
3836
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Understanding the fundamental alterations in brain functioning that lead to psychotic disorders remains a major challenge in clinical neuroscience. In particular, it is unknown whether any state-independent biomarkers can potentially predict the onset of psychosis and distinguish patients from healthy controls, regardless of paradigm. Here, using multi-paradigm fMRI data from the North American Prodrome Longitudinal Study consortium, we show that individuals at clinical high risk for psychosis display an intrinsic "trait-like" abnormality in brain architecture characterized as increased connectivity in the cerebello-thalamo-cortical circuitry, a pattern that is significantly more pronounced among converters compared with non-converters. This alteration is significantly correlated with disorganization symptoms and predictive of time to conversion to psychosis. Moreover, using an independent clinical sample, we demonstrate that this hyperconnectivity pattern is reliably detected and specifically present in patients with schizophrenia. These findings implicate cerebello-thalamo-cortical hyperconnectivity as a robust state-independent neural signature for psychosis prediction and characterization.
Keywords
Brain/abnormalities, Case-Control Studies, Cohort Studies, Connectome, Humans, Magnetic Resonance Imaging, Principal Component Analysis, Psychotic Disorders/diagnostic imaging, Psychotic Disorders/etiology, Schizophrenia/diagnostic imaging, Schizophrenia/etiology
Pubmed
Web of science
Open Access
Yes
Create date
11/01/2024 19:05
Last modification date
18/01/2024 16:09
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