Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland.

Details

Serval ID
serval:BIB_EF468599D088
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland.
Journal
Infection
Author(s)
Coste A.T., Kritikos A., Li J., Khanna N., Goldenberger D., Garzoni C., Zehnder C., Boggian K., Neofytos D., Riat A., Bachmann D., Sanglard D., Lamoth F.
Working group(s)
Fungal Infection Network of Switzerland (FUNGINOS)
Contributor(s)
Lamoth F., Khanna N., Boggian K., Sanglard D.
ISSN
1439-0973 (Electronic)
ISSN-L
0300-8126
Publication state
Published
Issued date
13/07/2020
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Echinocandins represent the first-line therapy of candidemia. Echinocandin resistance among Candida spp. is mainly due to acquired FKS mutations. In this study, we report the emergence of FKS-mutant Candida albicans/glabrata in Switzerland and provide the microbiological and clinical characteristics of 9 candidemic episodes. All patients were previously exposed to echinocandins (median 26 days; range 15-77). Five patients received initial echinocandin therapy with persistent candidemia in 4 of them. Overall mortality was 33%.
Pubmed
Open Access
Yes
Create date
24/07/2020 12:38
Last modification date
28/07/2020 6:26
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