A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro.

Details

Serval ID
serval:BIB_EEF89794343D
Type
Article: article from journal or magazin.
Collection
Publications
Title
A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro.
Journal
Aids
Author(s)
Yoon W., Ma B.J., Fellay J., Huang W., Xia S.M., Zhang R., Shianna K.V., Liao H.X., Haynes B.F., Goldstein D.B., NIAID Center for HIV/AIDS Vaccine Immunology 
ISSN
1473-5571 (Electronic)
ISSN-L
0269-9370
Publication state
Published
Issued date
2010
Volume
24
Number
1
Pages
155-157
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., ExtramuralPublication Status: ppublish
Abstract
A single-nucleotide polymorphism (rs2395029) in the HCP5 gene associated with HLA-B*5701 is correlated with lower HIV-1 viral set point. The two allelic forms of coding region were ectopically expressed in TZM-bl cells for an effect on HIV-1 replication. No significant HIV-1 restriction was observed in the cells with infectivity assays throughout HIV-1 life cycle, suggesting that the association of HCP5 variant with viral control is likely due to HLA-B*5701-related effect or other functional variants in the haplotype or both.
Keywords
HIV Infections/genetics, HIV Infections/virology, HIV-1/genetics, HLA-B Antigens/genetics, Humans, Major Histocompatibility Complex/genetics, Polymorphism, Single Nucleotide, Viral Load
Pubmed
Web of science
Create date
01/03/2012 15:14
Last modification date
20/08/2019 16:16
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