Progressive multifocal leukoencephalopathy in two natalizumab-treated stepsisters: An intriguing coincidence.

Details

Serval ID
serval:BIB_EEF4B976E6D4
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Progressive multifocal leukoencephalopathy in two natalizumab-treated stepsisters: An intriguing coincidence.
Journal
Multiple sclerosis
Author(s)
Bacchetta F., Mathias A., Schluep M., Du Pasquier R.
ISSN
1477-0970 (Electronic)
ISSN-L
1352-4585
Publication state
Published
Issued date
02/2017
Peer-reviewed
Oui
Volume
23
Number
2
Pages
300-303
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Abstract
Natalizumab, a treatment used in multiple sclerosis (MS), is associated with cases of progressive multifocal leukoencephalopathy (PML).
We describe two cases of PML in related but not genetically apparented natalizumab-treated MS patients who are stepsisters. Reported cases/outcomes: While Patient 1 developed PML, Patient 2 was on natalizumab and had contacts with Patient 1. Patient 2 was diagnosed with PML 5 months after Patient 1.
The clinical and temporal data highly suggest that there was JC virus (JCV) transmission from one patient to the other with development of PML as primo-infection in Patient 2.

Keywords
Antibodies, Monoclonal, Humanized/therapeutic use, Antibodies, Viral/immunology, Brain/pathology, Female, Humans, JC Virus/immunology, JC Virus/pathogenicity, Leukoencephalopathy, Progressive Multifocal/diagnosis, Leukoencephalopathy, Progressive Multifocal/etiology, Leukoencephalopathy, Progressive Multifocal/pathology, Middle Aged, Multiple Sclerosis/complications, Multiple Sclerosis/drug therapy, Natalizumab/adverse effects, Natalizumab/therapeutic use, JC virus, Natalizumab, multiple sclerosis, progressive multifocal leukoencephalopathy, transmission
Pubmed
Web of science
Create date
14/02/2017 12:00
Last modification date
20/08/2019 17:16
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